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Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis.
Ding C, Shrestha R, Zhu X, Geller AE, Wu S, Woeste MR, Li W, Wang H, Yuan F, Xu R, Chariker JH, Hu X, Li H, Tieri D, Zhang HG, Rouchka EC, Mitchell R, Siskind LJ, Zhang X, Xu XG, McMasters KM, Yu Y, Yan J. Ding C, et al. Among authors: mitchell r. Nat Immunol. 2023 Feb;24(2):239-254. doi: 10.1038/s41590-022-01388-8. Epub 2023 Jan 5. Nat Immunol. 2023. PMID: 36604547 Free PMC article.
MIF-Dependent Control of Tumor Immunity.
Noe JT, Mitchell RA. Noe JT, et al. Front Immunol. 2020 Nov 25;11:609948. doi: 10.3389/fimmu.2020.609948. eCollection 2020. Front Immunol. 2020. PMID: 33324425 Free PMC article. Review.
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.
Morrissey SM, Zhang F, Ding C, Montoya-Durango DE, Hu X, Yang C, Wang Z, Yuan F, Fox M, Zhang HG, Guo H, Tieri D, Kong M, Watson CT, Mitchell RA, Zhang X, McMasters KM, Huang J, Yan J. Morrissey SM, et al. Cell Metab. 2021 Oct 5;33(10):2040-2058.e10. doi: 10.1016/j.cmet.2021.09.002. Epub 2021 Sep 23. Cell Metab. 2021. PMID: 34559989 Free PMC article.
Lactate supports a metabolic-epigenetic link in macrophage polarization.
Noe JT, Rendon BE, Geller AE, Conroy LR, Morrissey SM, Young LEA, Bruntz RC, Kim EJ, Wise-Mitchell A, Barbosa de Souza Rizzo M, Relich ER, Baby BV, Johnson LA, Affronti HC, McMasters KM, Clem BF, Gentry MS, Yan J, Wellen KE, Sun RC, Mitchell RA. Noe JT, et al. Among authors: mitchell ra. Sci Adv. 2021 Nov 12;7(46):eabi8602. doi: 10.1126/sciadv.abi8602. Epub 2021 Nov 12. Sci Adv. 2021. PMID: 34767443 Free PMC article.
The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression.
Geller AE, Shrestha R, Woeste MR, Guo H, Hu X, Ding C, Andreeva K, Chariker JH, Zhou M, Tieri D, Watson CT, Mitchell RA, Zhang HG, Li Y, Martin Ii RCG, Rouchka EC, Yan J. Geller AE, et al. Among authors: mitchell ra. Nat Commun. 2022 Feb 9;13(1):759. doi: 10.1038/s41467-022-28407-4. Nat Commun. 2022. PMID: 35140221 Free PMC article.
4,469 results