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Enzymatic reconstitution of ribosomal peptide backbone thioamidation.
Mahanta N, Liu A, Dong S, Nair SK, Mitchell DA. Mahanta N, et al. Among authors: mitchell da. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3030-3035. doi: 10.1073/pnas.1722324115. Epub 2018 Mar 5. Proc Natl Acad Sci U S A. 2018. PMID: 29507203 Free PMC article.
New developments in RiPP discovery, enzymology and engineering.
Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, Link AJ, Martínez B, Nair SK, Nicolet Y, Rebuffat S, Sahl HG, Sareen D, Schmidt EW, Schmitt L, Severinov K, Süssmuth RD, Truman AW, Wang H, Weng JK, van Wezel GP, Zhang Q, Zhong J, Piel J, Mitchell DA, Kuipers OP, van der Donk WA. Montalbán-López M, et al. Among authors: mitchell da. Nat Prod Rep. 2021 Jan 1;38(1):130-239. doi: 10.1039/d0np00027b. Epub 2020 Sep 16. Nat Prod Rep. 2021. PMID: 32935693 Free PMC article. Review.
Bioinformatics-Guided Expansion and Discovery of Graspetides.
Ramesh S, Guo X, DiCaprio AJ, De Lio AM, Harris LA, Kille BL, Pogorelov TV, Mitchell DA. Ramesh S, et al. Among authors: mitchell da. ACS Chem Biol. 2021 Dec 17;16(12):2787-2797. doi: 10.1021/acschembio.1c00672. Epub 2021 Nov 12. ACS Chem Biol. 2021. PMID: 34766760 Free PMC article.
A scalable platform to discover antimicrobials of ribosomal origin.
Ayikpoe RS, Shi C, Battiste AJ, Eslami SM, Ramesh S, Simon MA, Bothwell IR, Lee H, Rice AJ, Ren H, Tian Q, Harris LA, Sarksian R, Zhu L, Frerk AM, Precord TW, van der Donk WA, Mitchell DA, Zhao H. Ayikpoe RS, et al. Among authors: mitchell da. Nat Commun. 2022 Oct 17;13(1):6135. doi: 10.1038/s41467-022-33890-w. Nat Commun. 2022. PMID: 36253467 Free PMC article.
Antibacterial drug leads targeting isoprenoid biosynthesis.
Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Zhu W, et al. Among authors: mitchell da. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17. Proc Natl Acad Sci U S A. 2013. PMID: 23248302 Free PMC article.
586 results