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Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells.
Zhang KR, Jankowski CSR, Marshall R, Nair R, Más Gómez N, Alnemri A, Liu Y, Erler E, Ferrante J, Song Y, Bell BA, Baumann BH, Sterling J, Anderson B, Foshe S, Roof J, Fazelinia H, Spruce LA, Chuang JZ, Sung CH, Dhingra A, Boesze-Battaglia K, Chavali VRM, Rabinowitz JD, Mitchell CH, Dunaief JL. Zhang KR, et al. Among authors: mitchell ch. Dis Model Mech. 2023 Jul 1;16(7):dmm050066. doi: 10.1242/dmm.050066. Epub 2023 Jul 25. Dis Model Mech. 2023. PMID: 37401371 Free PMC article.
Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
Guha S, Baltazar GC, Tu LA, Liu J, Lim JC, Lu W, Argall A, Boesze-Battaglia K, Laties AM, Mitchell CH. Guha S, et al. Among authors: mitchell ch. J Neurochem. 2012 Aug;122(4):823-33. doi: 10.1111/j.1471-4159.2012.07804.x. Epub 2012 Jun 27. J Neurochem. 2012. PMID: 22639870 Free PMC article.
Autophagy in the eye: implications for ocular cell health.
Frost LS, Mitchell CH, Boesze-Battaglia K. Frost LS, et al. Among authors: mitchell ch. Exp Eye Res. 2014 Jul;124:56-66. doi: 10.1016/j.exer.2014.04.010. Epub 2014 May 6. Exp Eye Res. 2014. PMID: 24810222 Free PMC article. Review.
The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.
Lu W, Gómez NM, Lim JC, Guha S, O'Brien-Jenkins A, Coffey EE, Campagno KE, McCaughey SA, Laties AM, Carlsson LG, Mitchell CH. Lu W, et al. Among authors: mitchell ch. Front Pharmacol. 2018 Apr 19;9:242. doi: 10.3389/fphar.2018.00242. eCollection 2018. Front Pharmacol. 2018. PMID: 29725296 Free PMC article.
126 results