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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S. Drayman N, et al. Among authors: missiakas d. Science. 2021 Aug 20;373(6557):931-936. doi: 10.1126/science.abg5827. Epub 2021 Jul 20. Science. 2021. PMID: 34285133 Free PMC article.
Crystal structure of Bacillus anthracis transpeptidase enzyme CapD.
Wu R, Richter S, Zhang RG, Anderson VJ, Missiakas D, Joachimiak A. Wu R, et al. Among authors: missiakas d. J Biol Chem. 2009 Sep 4;284(36):24406-14. doi: 10.1074/jbc.M109.019034. Epub 2009 Jun 16. J Biol Chem. 2009. PMID: 19535342 Free PMC article.
A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2.
Cai X, Chen M, Prominski A, Lin Y, Ankenbruck N, Rosenberg J, Nguyen M, Shi J, Tomatsidou A, Randall G, Missiakas D, Fung J, Chang EB, Penaloza-MacMaster P, Tian B, Huang J. Cai X, et al. Among authors: missiakas d. Adv Sci (Weinh). 2022 Jan;9(2):e2103240. doi: 10.1002/advs.202103240. Epub 2021 Nov 10. Adv Sci (Weinh). 2022. PMID: 34761549 Free PMC article.
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2.
El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. El-Shennawy L, et al. Among authors: missiakas d. Nat Commun. 2022 Jan 20;13(1):405. doi: 10.1038/s41467-021-27893-2. Nat Commun. 2022. PMID: 35058437 Free PMC article.
A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection.
Hassler L, Wysocki J, Gelarden I, Sharma I, Tomatsidou A, Ye M, Gula H, Nicoleascu V, Randall G, Pshenychnyi S, Khurram N, Kanwar Y, Missiakas D, Henkin J, Yeldandi A, Batlle D. Hassler L, et al. Among authors: missiakas d. J Am Soc Nephrol. 2022 Jul;33(7):1293-1307. doi: 10.1681/ASN.2021091209. Epub 2022 Mar 2. J Am Soc Nephrol. 2022. PMID: 35236774 Free PMC article.
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