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Page 1
Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (Part 2).
Huang HC, Tremont SJ, Lee LF, Keller BT, Carpenter AJ, Wang CC, Banerjee SC, Both SR, Fletcher T, Garland DJ, Huang W, Jones C, Koeller KJ, Kolodziej SA, Li J, Manning RE, Mahoney MW, Miller RE, Mischke DA, Rath NP, Reinhard EJ, Tollefson MB, Vernier WF, Wagner GM, Rapp SR, Beaudry J, Glenn K, Regina K, Schuh JR, Smith ME, Trivedi JS, Reitz DB. Huang HC, et al. Among authors: mischke da. J Med Chem. 2005 Sep 8;48(18):5853-68. doi: 10.1021/jm0402162. J Med Chem. 2005. PMID: 16134951
Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.
Durley RC, Grapperhaus ML, Hickory BS, Massa MA, Wang JL, Spangler DP, Mischke DA, Parnas BL, Fobian YM, Rath NP, Honda DD, Zeng M, Connolly DT, Heuvelman DM, Witherbee BJ, Melton MA, Glenn KC, Krul ES, Smith ME, Sikorski JA. Durley RC, et al. Among authors: mischke da. J Med Chem. 2002 Aug 29;45(18):3891-904. doi: 10.1021/jm020038h. J Med Chem. 2002. PMID: 12190312
Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (Part 1).
Tremont SJ, Lee LF, Huang HC, Keller BT, Banerjee SC, Both SR, Carpenter AJ, Wang CC, Garland DJ, Huang W, Jones C, Koeller KJ, Kolodziej SA, Li J, Manning RE, Mahoney MW, Miller RE, Mischke DA, Rath NP, Fletcher T, Reinhard EJ, Tollefson MB, Vernier WF, Wagner GM, Rapp SR, Beaudry J, Glenn K, Regina K, Schuh JR, Smith ME, Trivedi JS, Reitz DB. Tremont SJ, et al. Among authors: mischke da. J Med Chem. 2005 Sep 8;48(18):5837-52. doi: 10.1021/jm040215+. J Med Chem. 2005. PMID: 16134950
Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein.
Durley RC, Grapperhaus ML, Massa MA, Mischke DA, Parnas BL, Fobian YM, Rath NP, Honda DD, Zeng M, Connolly DT, Heuvelman DM, Witherbee BJ, Glenn KC, Krul ES, Smith ME, Sikorski JA. Durley RC, et al. Among authors: mischke da. J Med Chem. 2000 Nov 30;43(24):4575-8. doi: 10.1021/jm000337b. J Med Chem. 2000. PMID: 11101348 No abstract available.
MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.
Kolodziej SA, Hockerman SL, DeCrescenzo GA, McDonald JJ, Mischke DA, Munie GE, Fletcher TR, Stehle N, Swearingen C, Becker DP. Kolodziej SA, et al. Among authors: mischke da. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3561-4. doi: 10.1016/j.bmcl.2010.04.111. Epub 2010 Apr 28. Bioorg Med Chem Lett. 2010. PMID: 20529685
Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective alpha-sulfone hydroxamates.
Kolodziej SA, Hockerman SL, Boehm TL, Carroll JN, DeCrescenzo GA, McDonald JJ, Mischke DA, Munie GE, Fletcher TR, Rico JG, Stehle NW, Swearingen C, Becker DP. Kolodziej SA, et al. Among authors: mischke da. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3557-60. doi: 10.1016/j.bmcl.2010.04.130. Epub 2010 May 23. Bioorg Med Chem Lett. 2010. PMID: 20529684
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Meyers MJ, Pelc M, Kamtekar S, Day J, Poda GI, Hall MK, Michener ML, Reitz BA, Mathis KJ, Pierce BS, Parikh MD, Mischke DA, Long SA, Parlow JJ, Anderson DR, Thorarensen A. Meyers MJ, et al. Among authors: mischke da. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1543-7. doi: 10.1016/j.bmcl.2010.01.078. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20137931
12 results