Misaghi S - Search Results

1

Slashing the timelines: Opting to generate high-titer clonal lines faster via viability-based single cell sorting.

Misaghi S, Shaw D, Louie S, Nava A, Simmons L, Snedecor B, Poon C, Paw JS, Gilmour-Appling L, Cupp JE. Misaghi S, et al. Biotechnol Prog. 2016 Jan-Feb;32(1):198-207. doi: 10.1002/btpr.2204. Epub 2015 Dec 12. Biotechnol Prog. 2016. PMID: 26587808

2

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation.

Qu Y, Misaghi S, Newton K, Gilmour LL, Louie S, Cupp JE, Dubyak GR, Hackos D, Dixit VM. Qu Y, et al. Among authors: misaghi s. J Immunol. 2011 Jun 1;186(11):6553-61. doi: 10.4049/jimmunol.1100478. Epub 2011 Apr 20. J Immunol. 2011. PMID: 21508259

3

Phosphorylation of NLRC4 is critical for inflammasome activation.

Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM. Qu Y, et al. Among authors: misaghi s. Nature. 2012 Oct 25;490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12. Nature. 2012. PMID: 22885697

4

Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production.

Misaghi S, Qu Y, Snowden A, Chang J, Snedecor B. Misaghi S, et al. Biotechnol Prog. 2013 May-Jun;29(3):727-37. doi: 10.1002/btpr.1722. Epub 2013 Apr 18. Biotechnol Prog. 2013. PMID: 23596153

5

Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell.

Hu Z, Guo D, Yip SS, Zhan D, Misaghi S, Joly JC, Snedecor BR, Shen AY. Hu Z, et al. Among authors: misaghi s. Biotechnol Prog. 2013 Jul-Aug;29(4):980-5. doi: 10.1002/btpr.1730. Epub 2013 Apr 18. Biotechnol Prog. 2013. PMID: 23606666

6

It's time to regulate: coping with product-induced nongenetic clonal instability in CHO cell lines via regulated protein expression.

Misaghi S, Chang J, Snedecor B. Misaghi S, et al. Biotechnol Prog. 2014 Nov-Dec;30(6):1432-40. doi: 10.1002/btpr.1970. Epub 2014 Aug 16. Biotechnol Prog. 2014. PMID: 25104235

7

Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells.

Hu Z, Zhang H, Haley B, Macchi F, Yang F, Misaghi S, Elich J, Yang R, Tang Y, Joly JC, Snedecor BR, Shen A. Hu Z, et al. Among authors: misaghi s. Biotechnol Bioeng. 2016 Oct;113(10):2100-6. doi: 10.1002/bit.25977. Epub 2016 Apr 6. Biotechnol Bioeng. 2016. PMID: 26989081

8

FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.

Louie S, Haley B, Marshall B, Heidersbach A, Yim M, Brozynski M, Tang D, Lam C, Petryniak B, Shaw D, Shim J, Miller A, Lowe JB, Snedecor B, Misaghi S. Louie S, et al. Among authors: misaghi s. Biotechnol Bioeng. 2017 Mar;114(3):632-644. doi: 10.1002/bit.26188. Epub 2016 Oct 4. Biotechnol Bioeng. 2017. PMID: 27666939

9

Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells.

Lam C, Santell L, Wilson B, Yim M, Louie S, Tang D, Shaw D, Chan P, Lazarus RA, Snedecor B, Misaghi S. Lam C, et al. Among authors: misaghi s. Biotechnol Prog. 2017 Mar;33(2):523-533. doi: 10.1002/btpr.2439. Epub 2017 Feb 6. Biotechnol Prog. 2017. PMID: 28127892

10

Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells.

Hu Z, Tang D, Misaghi S, Jiang G, Yu C, Yim M, Shaw D, Snedecor B, Laird MW, Shen A. Hu Z, et al. Among authors: misaghi s. Biotechnol Prog. 2017 May;33(3):786-794. doi: 10.1002/btpr.2444. Epub 2017 Mar 24. Biotechnol Prog. 2017. PMID: 28188688

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