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A topological refactoring design strategy yields highly stable granulopoietic proteins.
Skokowa J, Hernandez Alvarez B, Coles M, Ritter M, Nasri M, Haaf J, Aghaallaei N, Xu Y, Mir P, Krahl AC, Rogers KW, Maksymenko K, Bajoghli B, Welte K, Lupas AN, Müller P, ElGamacy M. Skokowa J, et al. Among authors: mir p. Nat Commun. 2022 May 26;13(1):2948. doi: 10.1038/s41467-022-30157-2. Nat Commun. 2022. PMID: 35618709 Free PMC article.
Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.
Dannenmann B, Zahabi A, Mir P, Oswald B, Bernhard R, Klimiankou M, Morishima T, Schulze-Osthoff K, Zeidler C, Kanz L, Lachmann N, Moritz T, Welte K, Skokowa J. Dannenmann B, et al. Among authors: mir p. Exp Hematol. 2019 Mar;71:51-60. doi: 10.1016/j.exphem.2018.12.006. Epub 2019 Jan 4. Exp Hematol. 2019. PMID: 30615903 Free article.
CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.
Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, Makaryan V, Xu Y, Fletcher B, Bernhard R, Steiert I, Hahnel K, Berger J, Koch I, Sailer B, Hipp K, Zeidler C, Klimiankou M, Bajoghli B, Dale DC, Welte K, Skokowa J. Nasri M, et al. Among authors: mir p. Haematologica. 2020 Mar;105(3):598-609. doi: 10.3324/haematol.2019.221804. Epub 2019 Jun 27. Haematologica. 2020. PMID: 31248972 Free PMC article.
New insights into the pathomechanism of cyclic neutropenia.
Mir P, Klimiankou M, Findik B, Hähnel K, Mellor-Heineke S, Zeidler C, Skokowa J, Welte K. Mir P, et al. Ann N Y Acad Sci. 2020 Apr;1466(1):83-92. doi: 10.1111/nyas.14309. Epub 2020 Feb 21. Ann N Y Acad Sci. 2020. PMID: 32083314
Design of novel granulopoietic proteins by topological rescaffolding.
Hernandez Alvarez B, Skokowa J, Coles M, Mir P, Nasri M, Maksymenko K, Weidmann L, Rogers KW, Welte K, Lupas AN, Müller P, ElGamacy M. Hernandez Alvarez B, et al. Among authors: mir p. PLoS Biol. 2020 Dec 22;18(12):e3000919. doi: 10.1371/journal.pbio.3000919. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33351791 Free PMC article.
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.
Dannenmann B, Klimiankou M, Oswald B, Solovyeva A, Mardan J, Nasri M, Ritter M, Zahabi A, Arreba-Tutusaus P, Mir P, Stein F, Kandabarau S, Lachmann N, Moritz T, Morishima T, Konantz M, Lengerke C, Ripperger T, Steinemann D, Erlacher M, Niemeyer CM, Zeidler C, Welte K, Skokowa J. Dannenmann B, et al. Among authors: mir p. Cell Stem Cell. 2021 May 6;28(5):906-922.e6. doi: 10.1016/j.stem.2021.03.023. Epub 2021 Apr 23. Cell Stem Cell. 2021. PMID: 33894142 Free article.
408 results