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Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice.
Liu Y, Reiken S, Dridi H, Yuan Q, Mohammad KS, Trivedi T, Miotto MC, Wedderburn-Pugh K, Sittenfeld L, Kerley Y, Meyer JA, Peters JS, Persohn SC, Bedwell AA, Figueiredo LL, Suresh S, She Y, Soni RK, Territo PR, Marks AR, Guise TA. Liu Y, et al. Among authors: miotto mc. Sci Transl Med. 2023 Sep 27;15(715):eadf8977. doi: 10.1126/scitranslmed.adf8977. Epub 2023 Sep 27. Sci Transl Med. 2023. PMID: 37756377
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential.
Stutzman MJ, Kim CSJ, Tester DJ, Hamrick SK, Dotzler SM, Giudicessi JR, Miotto MC, Gc JB, Frank J, Marks AR, Ackerman MJ. Stutzman MJ, et al. Among authors: miotto mc. Stem Cell Reports. 2022 Sep 13;17(9):2023-2036. doi: 10.1016/j.stemcr.2022.07.002. Epub 2022 Aug 4. Stem Cell Reports. 2022. PMID: 35931078 Free PMC article.
Aroylhydrazones constitute a promising class of 'metal-protein attenuating compounds' for the treatment of Alzheimer's disease: a proof-of-concept based on the study of the interactions between zinc(II) and pyridine-2-carboxaldehyde isonicotinoyl hydrazone.
Cukierman DS, Accardo E, Gomes RG, De Falco A, Miotto MC, Freitas MCR, Lanznaster M, Fernández CO, Rey NA. Cukierman DS, et al. Among authors: miotto mc. J Biol Inorg Chem. 2018 Dec;23(8):1227-1241. doi: 10.1007/s00775-018-1606-0. Epub 2018 Aug 25. J Biol Inorg Chem. 2018. PMID: 30145655
18 results