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22 results

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Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Payton M, Belmontes B, Hanestad K, Moriguchi J, Chen K, McCarter JD, Chung G, Ninniri MS, Sun J, Manoukian R, Chambers S, Ho SM, Kurzeja RJM, Edson KZ, Dahal UP, Wu T, Wannberg S, Beltran PJ, Canon J, Boghossian AS, Rees MG, Ronan MM, Roth JA, Minocherhomji S, Bourbeau MP, Allen JR, Coxon A, Tamayo NA, Hughes PE. Payton M, et al. Among authors: minocherhomji s. Nat Cancer. 2024 Jan;5(1):66-84. doi: 10.1038/s43018-023-00699-5. Epub 2023 Dec 27. Nat Cancer. 2024. PMID: 38151625 Free PMC article.
Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.
Marchetti F, Cardoso R, Chen CL, Douglas GR, Elloway J, Escobar PA, Harper T Jr, Heflich RH, Kidd D, Lynch AM, Myers MB, Parsons BL, Salk JJ, Settivari RS, Smith-Roe SL, Witt KL, Yauk CL, Young R, Zhang S, Minocherhomji S. Marchetti F, et al. Among authors: minocherhomji s. Mutat Res Rev Mutat Res. 2023 Jul-Dec;792:108466. doi: 10.1016/j.mrrev.2023.108466. Epub 2023 Aug 27. Mutat Res Rev Mutat Res. 2023. PMID: 37643677 Free article. Review.
Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing.
Marchetti F, Cardoso R, Chen CL, Douglas GR, Elloway J, Escobar PA, Harper T Jr, Heflich RH, Kidd D, Lynch AM, Myers MB, Parsons BL, Salk JJ, Settivari RS, Smith-Roe SL, Witt KL, Yauk C, Young RR, Zhang S, Minocherhomji S. Marchetti F, et al. Among authors: minocherhomji s. Nat Rev Drug Discov. 2023 Mar;22(3):165-166. doi: 10.1038/d41573-023-00014-y. Nat Rev Drug Discov. 2023. PMID: 36646809 No abstract available.
AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations.
Cho E, Allemang A, Audebert M, Chauhan V, Dertinger S, Hendriks G, Luijten M, Marchetti F, Minocherhomji S, Pfuhler S, Roberts DJ, Trenz K, Yauk CL. Cho E, et al. Among authors: minocherhomji s. Environ Mol Mutagen. 2022 Mar;63(3):118-134. doi: 10.1002/em.22479. Epub 2022 May 3. Environ Mol Mutagen. 2022. PMID: 35315142 Free PMC article.
Permitted daily exposure limits for noteworthy N-nitrosamines.
Johnson GE, Dobo K, Gollapudi B, Harvey J, Kenny J, Kenyon M, Lynch A, Minocherhomji S, Nicolette J, Thybaud V, Wheeldon R, Zeller A. Johnson GE, et al. Among authors: minocherhomji s. Environ Mol Mutagen. 2021 Jun;62(5):293-305. doi: 10.1002/em.22446. Environ Mol Mutagen. 2021. PMID: 34089278
Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.
Valentine CC 3rd, Young RR, Fielden MR, Kulkarni R, Williams LN, Li T, Minocherhomji S, Salk JJ. Valentine CC 3rd, et al. Among authors: minocherhomji s. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33414-33425. doi: 10.1073/pnas.2013724117. Epub 2020 Dec 14. Proc Natl Acad Sci U S A. 2020. PMID: 33318186 Free PMC article.
The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them.
Smith MT, Guyton KZ, Kleinstreuer N, Borrel A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson WH 3rd, Houck KA, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden M. Smith MT, et al. Among authors: minocherhomji s. Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):1887-1903. doi: 10.1158/1055-9965.EPI-19-1346. Epub 2020 Mar 9. Cancer Epidemiol Biomarkers Prev. 2020. PMID: 32152214 Free PMC article.
22 results