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Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker.
Berkut AA, Chugunov AO, Mineev KS, Peigneur S, Tabakmakher VM, Krylov NA, Oparin PB, Lihonosova AF, Novikova EV, Arseniev AS, Grishin EV, Tytgat J, Efremov RG, Vassilevski AA. Berkut AA, et al. Among authors: mineev ks. J Biol Chem. 2019 Nov 29;294(48):18349-18359. doi: 10.1074/jbc.RA119.010494. Epub 2019 Sep 18. J Biol Chem. 2019. PMID: 31533989 Free PMC article.
Artificial pore blocker acts specifically on voltage-gated potassium channel isoform KV1.6.
Gigolaev AM, Lushpa VA, Pinheiro-Junior EL, Tabakmakher VM, Peigneur S, Ignatova AA, Feofanov AV, Efremov RG, Mineev KS, Tytgat J, Vassilevski AA. Gigolaev AM, et al. Among authors: mineev ks. J Biol Chem. 2022 Nov;298(11):102467. doi: 10.1016/j.jbc.2022.102467. Epub 2022 Sep 8. J Biol Chem. 2022. PMID: 36087839 Free PMC article.
Apamin structure and pharmacology revisited.
Kuzmenkov AI, Peigneur S, Nasburg JA, Mineev KS, Nikolaev MV, Pinheiro-Junior EL, Arseniev AS, Wulff H, Tytgat J, Vassilevski AA. Kuzmenkov AI, et al. Among authors: mineev ks. Front Pharmacol. 2022 Sep 16;13:977440. doi: 10.3389/fphar.2022.977440. eCollection 2022. Front Pharmacol. 2022. PMID: 36188602 Free PMC article.
83 results