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412 results

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Page 1
Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations.
Alqazzaz MA, Luciani GM, Vu V, Machado RAC, Szewczyk MM, Adamson EC, Cheon S, Li F, Arrowsmith CH, Minden MD, Barsyte-Lovejoy D. Alqazzaz MA, et al. Among authors: minden md. Exp Hematol. 2024 Feb;130:104135. doi: 10.1016/j.exphem.2023.11.009. Epub 2023 Dec 10. Exp Hematol. 2024. PMID: 38072134
Flow cytometry-based measurable residual disease (MRD) analysis identifies AML patients who may benefit from allogeneic hematopoietic stem cell transplantation.
Lucero J, Alhumaid M, Novitzky-Basso I, Capo-Chichi JM, Stockley T, Gupta V, Bankar A, Chan S, Schuh AC, Minden M, Mattsson J, Kumar R, Sibai H, Tierens A, Kim DDH. Lucero J, et al. Ann Hematol. 2024 Apr;103(4):1187-1196. doi: 10.1007/s00277-024-05639-6. Epub 2024 Jan 30. Ann Hematol. 2024. PMID: 38291275
Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia.
Kim JC, Chan-Seng-Yue M, Ge S, Zeng AGX, Ng K, Gan OI, Garcia-Prat L, Flores-Figueroa E, Woo T, Zhang AXW, Arruda A, Chithambaram S, Dobson SM, Khoo A, Khan S, Ibrahimova N, George A, Tierens A, Hitzler J, Kislinger T, Dick JE, McPherson JD, Minden MD, Notta F. Kim JC, et al. Among authors: minden md. Nat Genet. 2023 Jul;55(7):1186-1197. doi: 10.1038/s41588-023-01429-4. Epub 2023 Jun 19. Nat Genet. 2023. PMID: 37337105 Free PMC article.
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
O'Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. O'Brien C, et al. Among authors: minden md. Haematologica. 2023 Sep 1;108(9):2343-2357. doi: 10.3324/haematol.2022.281894. Haematologica. 2023. PMID: 37021547 Free PMC article.
Biallelic disruption of DDX41 activity is associated with distinct genomic and immunophenotypic hallmarks in acute leukemia.
Tierens A, Kagotho E, Shinriki S, Seto A, Smith AC, Care M, Maze D, Sibai H, Yee KW, Schuh AC, Kim DDH, Gupta V, Minden MD, Matsui H, Capo-Chichi JM. Tierens A, et al. Among authors: minden md. Front Oncol. 2023 Jun 26;13:1153082. doi: 10.3389/fonc.2023.1153082. eCollection 2023. Front Oncol. 2023. PMID: 37434984 Free PMC article.
Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia.
de Castro FA, Mehdipour P, Chakravarthy A, Ettayebi I, Loo Yau H, Medina TS, Marhon SA, de Almeida FC, Bianco TM, Arruda AGF, Devlin R, de Figueiredo-Pontes LL, Chahud F, da Costa Cacemiro M, Minden MD, Gupta V, De Carvalho DD. de Castro FA, et al. Among authors: minden md. Br J Haematol. 2024 Jan;204(1):206-220. doi: 10.1111/bjh.19107. Epub 2023 Sep 19. Br J Haematol. 2024. PMID: 37726227
Exclusion of persistent mutations in splicing factor genes and isocitrate dehydrogenase 2 improves the prognostic power of molecular measurable residual disease assessment in acute myeloid leukemia.
Murphy T, Zou J, Arruda A, Wang TT, Zhao Z, Zheng Y, Gupta V, Maze D, McNamara C, Minden MD, Schimmer A, Sibai H, Yee K, Capo-Chichi JM, Stockley T, Schuh A, Bratman SV, Chan SM. Murphy T, et al. Among authors: minden md. Haematologica. 2024 Feb 1;109(2):671-675. doi: 10.3324/haematol.2023.283510. Haematologica. 2024. PMID: 37345484 Free PMC article. No abstract available.
Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure.
Su M, Fleischer T, Grosheva I, Horev MB, Olszewska M, Mattioli CC, Barr H, Plotnikov A, Carvalho S, Moskovich Y, Minden MD, Chapal-Ilani N, Wainstein A, Papapetrou EP, Dezorella N, Cheng T, Kaushansky N, Geiger B, Shlush LI. Su M, et al. Among authors: minden md. iScience. 2024 Mar 6;27(4):109443. doi: 10.1016/j.isci.2024.109443. eCollection 2024 Apr 19. iScience. 2024. PMID: 38558935 Free PMC article.
412 results