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Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.
Rosini M, Budriesi R, Bixel MG, Bolognesi ML, Chiarini A, Hucho F, Krogsgaard-Larsen P, Mellor IR, Minarini A, Tumiatti V, Usherwood PN, Melchiorre C. Rosini M, et al. Among authors: minarini a. J Med Chem. 1999 Dec 16;42(25):5212-23. doi: 10.1021/jm991110n. J Med Chem. 1999. PMID: 10602706
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms.
Rosini M, Bixel MG, Marucci G, Budriesi R, Krauss M, Bolognesi ML, Minarini A, Tumiatti V, Hucho F, Melchiorre C. Rosini M, et al. Among authors: minarini a. J Med Chem. 2002 Apr 25;45(9):1860-78. doi: 10.1021/jm011067f. J Med Chem. 2002. PMID: 11960498
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Tumiatti V, Rosini M, Bartolini M, Cavalli A, Marucci G, Andrisano V, Angeli P, Banzi R, Minarini A, Recanatini M, Melchiorre C. Tumiatti V, et al. Among authors: minarini a. J Med Chem. 2003 Mar 13;46(6):954-66. doi: 10.1021/jm021055+. J Med Chem. 2003. PMID: 12620072
Rational approach to discover multipotent anti-Alzheimer drugs.
Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C. Rosini M, et al. Among authors: minarini a. J Med Chem. 2005 Jan 27;48(2):360-3. doi: 10.1021/jm049112h. J Med Chem. 2005. PMID: 15658850
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
Rosini M, Simoni E, Bartolini M, Cavalli A, Ceccarini L, Pascu N, McClymont DW, Tarozzi A, Bolognesi ML, Minarini A, Tumiatti V, Andrisano V, Mellor IR, Melchiorre C. Rosini M, et al. Among authors: minarini a. J Med Chem. 2008 Aug 14;51(15):4381-4. doi: 10.1021/jm800577j. Epub 2008 Jul 8. J Med Chem. 2008. PMID: 18605718
113 results