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Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features.
Rao S, Verrill C, Cerundolo L, Alham NK, Kaya Z, O'Hanlon M, Hayes A, Lambert A, James M, Tullis IDC, Niederer J, Lovell S, Omer A, Lopez F, Leslie T, Buffa F, Bryant RJ, Lamb AD, Vojnovic B, Wedge DC, Mills IG, Woodcock DJ, Tomlinson I, Hamdy FC. Rao S, et al. Among authors: mills ig. Genome Med. 2024 Feb 19;16(1):35. doi: 10.1186/s13073-024-01302-x. Genome Med. 2024. PMID: 38374116 Free PMC article.
Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using Mendelian randomization and tumor spatial transcriptomics.
Desai TA, Hedman ÅK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL, Atkins JR, Sokolov AV, Schiöth HB, Gunter MJ, Tsilidis KK, Martin RM, Pietzner M, Langenberg C, Mills IG, Lamb AD, Mälarstig A, Key TJ; PRACTICAL Consortium; Travis RC, Smith-Byrne K. Desai TA, et al. Among authors: mills ig. medRxiv [Preprint]. 2023 Sep 22:2023.09.21.23295864. doi: 10.1101/2023.09.21.23295864. medRxiv. 2023. PMID: 37790472 Free PMC article. Preprint.
Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells.
Steiner I, Flores-Tellez TDNJ, Mevel R, Ali A, Wang P, Schofield P, Behan C, Forsythe N, Ashton G, Taylor C, Mills IG, Oliveira P, McDade SS, Zaiss DM, Choudhury A, Lacaud G, Baena E. Steiner I, et al. Among authors: mills ig. Cell Rep. 2023 Apr 25;42(4):112377. doi: 10.1016/j.celrep.2023.112377. Epub 2023 Apr 14. Cell Rep. 2023. PMID: 37060563 Free article.
Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1.
Mukherjee D, Romano E, Walshaw R, Zeef LAH, Banyard A, Kitcatt SJ, Cheadle EJ, Tuomela K, Pendharkar S, Al-Deka A, Salerno B, Raby S, Mills IG, Honeychurch J, Illidge TM. Mukherjee D, et al. Among authors: mills ig. Oncoimmunology. 2023 Jun 15;12(1):2223094. doi: 10.1080/2162402X.2023.2223094. eCollection 2023. Oncoimmunology. 2023. PMID: 37332616 Free PMC article.
201 results