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Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer.
Xiao R, You L, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, Wang Z, Liu C, Peng W, Li W, Yang X, Dou Y, Liu J, Wang W, Qin T, Cui Y, Zhang X, Li F, Jin Y, Zeng Q, Wang B, Mills GB, Chen G, Sheng X, Sun C. Xiao R, et al. Among authors: mills gb. Adv Sci (Weinh). 2022 Jul;9(21):e2105469. doi: 10.1002/advs.202105469. Epub 2022 May 26. Adv Sci (Weinh). 2022. PMID: 35619328 Free PMC article.
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
Sun C, Fang Y, Yin J, Chen J, Ju Z, Zhang D, Chen X, Vellano CP, Jeong KJ, Ng PK, Eterovic AKB, Bhola NH, Lu Y, Westin SN, Grandis JR, Lin SY, Scott KL, Peng G, Brugge J, Mills GB. Sun C, et al. Among authors: mills gb. Sci Transl Med. 2017 May 31;9(392):eaal5148. doi: 10.1126/scitranslmed.aal5148. Sci Transl Med. 2017. PMID: 28566428 Free PMC article.
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.
Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB. Sun C, et al. Among authors: mills gb. Cancer Cell. 2018 Mar 12;33(3):401-416.e8. doi: 10.1016/j.ccell.2018.01.019. Cancer Cell. 2018. PMID: 29533782 Free PMC article.
Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Fang Y, et al. Among authors: mills gb. Cancer Cell. 2019 Jun 10;35(6):851-867.e7. doi: 10.1016/j.ccell.2019.05.001. Cancer Cell. 2019. PMID: 31185210 Free PMC article.
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills GB, Sun C, Chen G. Guo E, et al. Among authors: mills gb. J Exp Med. 2022 Jan 3;219(1):e20210789. doi: 10.1084/jem.20210789. Epub 2021 Nov 26. J Exp Med. 2022. PMID: 34825915 Free PMC article.
1,134 results