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Page 1
De novo design of protein structure and function with RFdiffusion.
Watson JL, Juergens D, Bennett NR, Trippe BL, Yim J, Eisenach HE, Ahern W, Borst AJ, Ragotte RJ, Milles LF, Wicky BIM, Hanikel N, Pellock SJ, Courbet A, Sheffler W, Wang J, Venkatesh P, Sappington I, Torres SV, Lauko A, De Bortoli V, Mathieu E, Ovchinnikov S, Barzilay R, Jaakkola TS, DiMaio F, Baek M, Baker D. Watson JL, et al. Among authors: milles lf. Nature. 2023 Aug;620(7976):1089-1100. doi: 10.1038/s41586-023-06415-8. Epub 2023 Jul 11. Nature. 2023. PMID: 37433327 Free PMC article.
Scaffolding protein functional sites using deep learning.
Wang J, Lisanza S, Juergens D, Tischer D, Watson JL, Castro KM, Ragotte R, Saragovi A, Milles LF, Baek M, Anishchenko I, Yang W, Hicks DR, Expòsit M, Schlichthaerle T, Chun JH, Dauparas J, Bennett N, Wicky BIM, Muenks A, DiMaio F, Correia B, Ovchinnikov S, Baker D. Wang J, et al. Among authors: milles lf. Science. 2022 Jul 22;377(6604):387-394. doi: 10.1126/science.abn2100. Epub 2022 Jul 21. Science. 2022. PMID: 35862514 Free PMC article.
Hallucinating symmetric protein assemblies.
Wicky BIM, Milles LF, Courbet A, Ragotte RJ, Dauparas J, Kinfu E, Tipps S, Kibler RD, Baek M, DiMaio F, Li X, Carter L, Kang A, Nguyen H, Bera AK, Baker D. Wicky BIM, et al. Among authors: milles lf. Science. 2022 Oct 7;378(6615):56-61. doi: 10.1126/science.add1964. Epub 2022 Sep 15. Science. 2022. PMID: 36108048 Free PMC article.
Robust deep learning-based protein sequence design using ProteinMPNN.
Dauparas J, Anishchenko I, Bennett N, Bai H, Ragotte RJ, Milles LF, Wicky BIM, Courbet A, de Haas RJ, Bethel N, Leung PJY, Huddy TF, Pellock S, Tischer D, Chan F, Koepnick B, Nguyen H, Kang A, Sankaran B, Bera AK, King NP, Baker D. Dauparas J, et al. Among authors: milles lf. Science. 2022 Oct 7;378(6615):49-56. doi: 10.1126/science.add2187. Epub 2022 Sep 15. Science. 2022. PMID: 36108050 Free PMC article.
De novo design of small beta barrel proteins.
Kim DE, Jensen DR, Feldman D, Tischer D, Saleem A, Chow CM, Li X, Carter L, Milles L, Nguyen H, Kang A, Bera AK, Peterson FC, Volkman BF, Ovchinnikov S, Baker D. Kim DE, et al. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2207974120. doi: 10.1073/pnas.2207974120. Epub 2023 Mar 10. Proc Natl Acad Sci U S A. 2023. PMID: 36897987 Free PMC article.
Hallucination of closed repeat proteins containing central pockets.
An L, Hicks DR, Zorine D, Dauparas J, Wicky BIM, Milles LF, Courbet A, Bera AK, Nguyen H, Kang A, Carter L, Baker D. An L, et al. Among authors: milles lf. Nat Struct Mol Biol. 2023 Nov;30(11):1755-1760. doi: 10.1038/s41594-023-01112-6. Epub 2023 Sep 28. Nat Struct Mol Biol. 2023. PMID: 37770718 Free PMC article.
De novo design of knotted tandem repeat proteins.
Doyle LA, Takushi B, Kibler RD, Milles LF, Orozco CT, Jones JD, Jackson SE, Stoddard BL, Bradley P. Doyle LA, et al. Among authors: milles lf. Nat Commun. 2023 Oct 24;14(1):6746. doi: 10.1038/s41467-023-42388-y. Nat Commun. 2023. PMID: 37875492 Free PMC article.
From genes to protein mechanics on a chip.
Otten M, Ott W, Jobst MA, Milles LF, Verdorfer T, Pippig DA, Nash MA, Gaub HE. Otten M, et al. Among authors: milles lf. Nat Methods. 2014 Nov;11(11):1127-1130. doi: 10.1038/nmeth.3099. Epub 2014 Sep 7. Nat Methods. 2014. PMID: 25194847 Free PMC article.
Ultrastable cellulosome-adhesion complex tightens under load.
Schoeler C, Malinowska KH, Bernardi RC, Milles LF, Jobst MA, Durner E, Ott W, Fried DB, Bayer EA, Schulten K, Gaub HE, Nash MA. Schoeler C, et al. Among authors: milles lf. Nat Commun. 2014 Dec 8;5:5635. doi: 10.1038/ncomms6635. Nat Commun. 2014. PMID: 25482395 Free PMC article.
28 results