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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA. Watson ER, et al. Among authors: miller dj. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26. Proc Natl Acad Sci U S A. 2019. PMID: 31350353 Free PMC article.
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
Wang J, Buchman CD, Seetharaman J, Miller DJ, Huber AD, Wu J, Chai SC, Garcia-Maldonado E, Wright WC, Chenge J, Chen T. Wang J, et al. Among authors: miller dj. J Am Chem Soc. 2021 Nov 10;143(44):18467-18480. doi: 10.1021/jacs.1c07066. Epub 2021 Oct 14. J Am Chem Soc. 2021. PMID: 34648292 Free PMC article.
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB 3rd, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. Pan M, et al. Nat Commun. 2021 Nov 9;12(1):6468. doi: 10.1038/s41467-021-26640-x. Nat Commun. 2021. PMID: 34753908 Free PMC article.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG. Reshetnyak AV, et al. Among authors: miller dj. Nature. 2021 Dec;600(7887):153-157. doi: 10.1038/s41586-021-04140-8. Epub 2021 Nov 24. Nature. 2021. PMID: 34819673 Free PMC article.
863 results