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Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.
Chan WW, Wise SC, Kaufman MD, Ahn YM, Ensinger CL, Haack T, Hood MM, Jones J, Lord JW, Lu WP, Miller D, Patt WC, Smith BD, Petillo PA, Rutkoski TJ, Telikepalli H, Vogeti L, Yao T, Chun L, Clark R, Evangelista P, Gavrilescu LC, Lazarides K, Zaleskas VM, Stewart LJ, Van Etten RA, Flynn DL. Chan WW, et al. Among authors: miller d. Cancer Cell. 2011 Apr 12;19(4):556-68. doi: 10.1016/j.ccr.2011.03.003. Cancer Cell. 2011. PMID: 21481795 Free PMC article.
Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.
Ahn YM, Clare M, Ensinger CL, Hood MM, Lord JW, Lu WP, Miller DF, Patt WC, Smith BD, Vogeti L, Kaufman MD, Petillo PA, Wise SC, Abendroth J, Chun L, Clark R, Feese M, Kim H, Stewart L, Flynn DL. Ahn YM, et al. Among authors: miller df. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5793-8. doi: 10.1016/j.bmcl.2010.07.134. Epub 2010 Aug 3. Bioorg Med Chem Lett. 2010. PMID: 20800479
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL. Henry JR, et al. Among authors: miller d. J Med Chem. 2015 May 28;58(10):4165-79. doi: 10.1021/acs.jmedchem.5b00067. Epub 2015 May 12. J Med Chem. 2015. PMID: 25965804
Erratum: Sociome Data Commons: A scalable and sustainable platform for investigating the full social context and determinants of health - ERRATUM.
Tilmon S, Nyenhuis S, Solomonides A, Barbarioli B, Bhargava A, Birz S, Bouzein K, Cardenas C, Carlson B, Cohen E, Dillon E, Furner B, Huang Z, Johnson J, Krishnan N, Lazenby K, Li K, Makhni S, Miller D, Ozik J, Santos C, Sleiman M, Solway J, Krishnan S, Volchenbouma S. Tilmon S, et al. Among authors: miller d. J Clin Transl Sci. 2024 May 13;8(1):e82. doi: 10.1017/cts.2024.537. eCollection 2024. J Clin Transl Sci. 2024. PMID: 38745878 Free PMC article.
Exploring the Impact of Nickel Exposure on Female Fertility.
Ganz M, Devor S, Gejerman Y, Benyaminov T, Ishakis Y, Bulmash M, Miller D. Ganz M, et al. Among authors: miller d. Cureus. 2024 Apr 5;16(4):e57681. doi: 10.7759/cureus.57681. eCollection 2024 Apr. Cureus. 2024. PMID: 38707078 Free PMC article.
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