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Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface.
Awad MM, Hutton ML, Quek AJ, Klare WP, Mileto SJ, Mackin K, Ly D, Oorschot V, Bosnjak M, Jenkin G, Conroy PJ, West N, Fulcher A, Costin A, Day CJ, Jennings MP, Medcalf RL, Sanderson-Smith M, Cordwell SJ, Law RHP, Whisstock JC, Lyras D. Awad MM, et al. Among authors: mileto sj. Gastroenterology. 2020 Oct;159(4):1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032. Epub 2020 Jun 20. Gastroenterology. 2020. PMID: 32574621
Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.
Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D. Mileto SJ, et al. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8064-8073. doi: 10.1073/pnas.1915255117. Epub 2020 Mar 20. Proc Natl Acad Sci U S A. 2020. PMID: 32198200 Free PMC article.
Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis.
Huang J, Kelly CP, Bakirtzi K, Villafuerte Gálvez JA, Lyras D, Mileto SJ, Larcombe S, Xu H, Yang X, Shields KS, Zhu W, Zhang Y, Goldsmith JD, Patel IJ, Hansen J, Huang M, Yla-Herttuala S, Moss AC, Paredes-Sabja D, Pothoulakis C, Shah YM, Wang J, Chen X. Huang J, et al. Among authors: mileto sj. Nat Microbiol. 2019 Feb;4(2):269-279. doi: 10.1038/s41564-018-0300-x. Epub 2018 Dec 3. Nat Microbiol. 2019. PMID: 30510170 Free PMC article.
12 results