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Live pigs produced from genome edited zygotes.
Lillico SG, Proudfoot C, Carlson DF, Stverakova D, Neil C, Blain C, King TJ, Ritchie WA, Tan W, Mileham AJ, McLaren DG, Fahrenkrug SC, Whitelaw CB. Lillico SG, et al. Among authors: mileham aj. Sci Rep. 2013 Oct 10;3:2847. doi: 10.1038/srep02847. Sci Rep. 2013. PMID: 24108318 Free PMC article.
Genome edited sheep and cattle.
Proudfoot C, Carlson DF, Huddart R, Long CR, Pryor JH, King TJ, Lillico SG, Mileham AJ, McLaren DG, Whitelaw CB, Fahrenkrug SC. Proudfoot C, et al. Among authors: mileham aj. Transgenic Res. 2015 Feb;24(1):147-53. doi: 10.1007/s11248-014-9832-x. Epub 2014 Sep 10. Transgenic Res. 2015. PMID: 25204701 Free PMC article.
Substitution of warthog NF-κB motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus.
McCleary S, Strong R, McCarthy RR, Edwards JC, Howes EL, Stevens LM, Sánchez-Cordón PJ, Núñez A, Watson S, Mileham AJ, Lillico SG, Tait-Burkard C, Proudfoot C, Ballantyne M, Whitelaw CBA, Steinbach F, Crooke HR. McCleary S, et al. Among authors: mileham aj. Sci Rep. 2020 Jun 2;10(1):8951. doi: 10.1038/s41598-020-65808-1. Sci Rep. 2020. PMID: 32488046 Free PMC article.
Highly efficient targeted chromosome deletions using CRISPR/Cas9.
He Z, Proudfoot C, Mileham AJ, McLaren DG, Whitelaw CB, Lillico SG. He Z, et al. Among authors: mileham aj. Biotechnol Bioeng. 2015 May;112(5):1060-4. doi: 10.1002/bit.25490. Epub 2014 Dec 23. Biotechnol Bioeng. 2015. PMID: 25362885
Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.
Burkard C, Lillico SG, Reid E, Jackson B, Mileham AJ, Ait-Ali T, Whitelaw CB, Archibald AL. Burkard C, et al. Among authors: mileham aj. PLoS Pathog. 2017 Feb 23;13(2):e1006206. doi: 10.1371/journal.ppat.1006206. eCollection 2017 Feb. PLoS Pathog. 2017. PMID: 28231264 Free PMC article.
Erratum for Burkard et al., "Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection".
Burkard C, Opriessnig T, Mileham AJ, Stadejek T, Ait-Ali T, Lillico SG, Whitelaw CBA, Archibald AL. Burkard C, et al. Among authors: mileham aj. J Virol. 2020 Jul 16;94(15):e00951-20. doi: 10.1128/JVI.00951-20. Print 2020 Jul 16. J Virol. 2020. PMID: 32675378 Free PMC article. No abstract available.
41 results