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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Blümel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, Wölfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, Stühler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S. Marquardt V, et al. Among authors: milde t. J Immunother Cancer. 2023 Jan;11(1):e005871. doi: 10.1136/jitc-2022-005871. J Immunother Cancer. 2023. PMID: 36639156 Free PMC article.
Emerging insights into the ependymoma epigenome.
Mack SC, Witt H, Wang X, Milde T, Yao Y, Bertrand KC, Korshunov A, Pfister SM, Taylor MD. Mack SC, et al. Among authors: milde t. Brain Pathol. 2013 Mar;23(2):206-9. doi: 10.1111/bpa.12020. Brain Pathol. 2013. PMID: 23432646 Free PMC article. Review.
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.
Shmelkov SV, Hormigo A, Jing D, Proenca CC, Bath KG, Milde T, Shmelkov E, Kushner JS, Baljevic M, Dincheva I, Murphy AJ, Valenzuela DM, Gale NW, Yancopoulos GD, Ninan I, Lee FS, Rafii S. Shmelkov SV, et al. Among authors: milde t. Nat Med. 2010 May;16(5):598-602, 1p following 602. doi: 10.1038/nm.2125. Epub 2010 Apr 25. Nat Med. 2010. PMID: 20418887 Free PMC article.
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.
Hooper AT, Shmelkov SV, Gupta S, Milde T, Bambino K, Gillen K, Goetz M, Chavala S, Baljevic M, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, Vahdat L, Evans T, Rafii S. Hooper AT, et al. Among authors: milde t. Circ Res. 2009 Jul 17;105(2):201-8. doi: 10.1161/CIRCRESAHA.109.196790. Epub 2009 Jun 18. Circ Res. 2009. PMID: 19542015 Free PMC article.
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, D'Angelica M, Kemeny N, Lyden D, Rafii S. Shmelkov SV, et al. Among authors: milde t. J Clin Invest. 2008 Jun;118(6):2111-20. doi: 10.1172/JCI34401. J Clin Invest. 2008. PMID: 18497886 Free PMC article.
HDAC family: What are the cancer relevant targets?
Witt O, Deubzer HE, Milde T, Oehme I. Witt O, et al. Among authors: milde t. Cancer Lett. 2009 May 8;277(1):8-21. doi: 10.1016/j.canlet.2008.08.016. Epub 2008 Sep 27. Cancer Lett. 2009. PMID: 18824292 Review.
Targeting histone deacetylases in neuroblastoma.
Witt O, Deubzer HE, Lodrini M, Milde T, Oehme I. Witt O, et al. Among authors: milde t. Curr Pharm Des. 2009;15(4):436-47. doi: 10.2174/138161209787315774. Curr Pharm Des. 2009. PMID: 19199971 Review.
150 results