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Targeting immunoproteasome in neurodegeneration: A glance to the future.
Tundo GR, Cascio P, Milardi D, Santoro AM, Graziani G, Lacal PM, Bocedi A, Oddone F, Parravano M, Coletta A, Coletta M, Sbardella D. Tundo GR, et al. Among authors: milardi d. Pharmacol Ther. 2023 Jan;241:108329. doi: 10.1016/j.pharmthera.2022.108329. Epub 2022 Dec 14. Pharmacol Ther. 2023. PMID: 36526014 Review.
Cationic porphyrins are reversible proteasome inhibitors.
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D. Santoro AM, et al. Among authors: milardi d, d urso a. J Am Chem Soc. 2012 Jun 27;134(25):10451-7. doi: 10.1021/ja300781u. Epub 2012 Jun 6. J Am Chem Soc. 2012. PMID: 22642538 Free article.
Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M. Tundo GR, et al. Among authors: milardi d. Crit Rev Biochem Mol Biol. 2017 Oct;52(5):554-582. doi: 10.1080/10409238.2017.1337707. Epub 2017 Jun 21. Crit Rev Biochem Mol Biol. 2017. PMID: 28635330 Review.
Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding.
Dato AD, Cunsolo A, Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M. Dato AD, et al. Among authors: milardi d, d urso a. Sci Rep. 2017 Dec 6;7(1):17098. doi: 10.1038/s41598-017-17008-7. Sci Rep. 2017. PMID: 29213119 Free PMC article.
Cationic porphyrins are tunable gatekeepers of the 20S proteasome.
Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R. Santoro AM, et al. Among authors: milardi d, d urso a. Chem Sci. 2016 Feb 1;7(2):1286-1297. doi: 10.1039/c5sc03312h. Epub 2015 Nov 9. Chem Sci. 2016. PMID: 29910886 Free PMC article.
Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways.
Bellia F, Lanza V, García-Viñuales S, Ahmed IMM, Pietropaolo A, Iacobucci C, Malgieri G, D'Abrosca G, Fattorusso R, Nicoletti VG, Sbardella D, Tundo GR, Coletta M, Pirone L, Pedone E, Calcagno D, Grasso G, Milardi D. Bellia F, et al. Among authors: milardi d, d abrosca g. Chem Sci. 2019 Jan 10;10(9):2732-2742. doi: 10.1039/c8sc03394c. eCollection 2019 Mar 7. Chem Sci. 2019. PMID: 30996991 Free PMC article.
Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity.
Santoro AM, Lanza V, Bellia F, Sbardella D, Tundo GR, Cannizzo A, Grasso G, Arizzi M, Nicoletti VG, Alcaro S, Costa G, Pietropaolo A, Malgieri G, D'Abrosca G, Fattorusso R, García-Viñuales S, Ahmed IMM, Coletta M, Milardi D. Santoro AM, et al. Among authors: milardi d, d abrosca g. ChemMedChem. 2020 Feb 5;15(3):302-316. doi: 10.1002/cmdc.201900612. Epub 2019 Dec 17. ChemMedChem. 2020. PMID: 31797568
Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations.
Sbardella D, Tundo GR, Cunsolo V, Grasso G, Cascella R, Caputo V, Santoro AM, Milardi D, Pecorelli A, Ciaccio C, Di Pierro D, Leoncini S, Campagnolo L, Pironi V, Oddone F, Manni P, Foti S, Giardina E, De Felice C, Hayek J, Curatolo P, Galasso C, Valacchi G, Coletta M, Graziani G, Marini S. Sbardella D, et al. Among authors: milardi d. Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165793. doi: 10.1016/j.bbadis.2020.165793. Epub 2020 Apr 8. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32275946 Free article.
286 results