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SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.
Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS. Dillenburg-Pilla P, et al. Among authors: mikelis cm. FASEB J. 2015 Mar;29(3):1056-68. doi: 10.1096/fj.14-260083. Epub 2014 Dec 2. FASEB J. 2015. PMID: 25466898 Free PMC article.
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.
Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. Mikelis CM, et al. Nat Commun. 2015 Apr 10;6:6725. doi: 10.1038/ncomms7725. Nat Commun. 2015. PMID: 25857352 Free PMC article.
Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.
O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS. O'Hayre M, et al. Among authors: mikelis cm. Oncogene. 2016 Jul 21;35(29):3771-80. doi: 10.1038/onc.2015.442. Epub 2015 Nov 30. Oncogene. 2016. PMID: 26616858 Free PMC article.
The homozygous CX3CR1-M280 mutation impairs human monocyte survival.
Collar AL, Swamydas M, O'Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, Lim JK, Mikelis CM, Gutkind JS, Lionakis MS. Collar AL, et al. Among authors: mikelis cm. JCI Insight. 2018 Feb 8;3(3):e95417. doi: 10.1172/jci.insight.95417. eCollection 2018 Feb 8. JCI Insight. 2018. PMID: 29415879 Free PMC article.
GM-CSF therapy in human caspase recruitment domain-containing protein 9 deficiency.
Drummond RA, Zahra FT, Natarajan M, Swamydas M, Hsu AP, Wheat LJ, Gavino C, Vinh DC, Holland SM, Mikelis CM, Lionakis MS. Drummond RA, et al. Among authors: mikelis cm. J Allergy Clin Immunol. 2018 Oct;142(4):1334-1338.e5. doi: 10.1016/j.jaci.2018.05.025. Epub 2018 Jun 8. J Allergy Clin Immunol. 2018. PMID: 29890237 No abstract available.
75 results