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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Carzaniga L, Linney ID, Rizzi A, Delcanale M, Schmidt W, Knight CK, Pastore F, Miglietta D, Carnini C, Cesari N, Riccardi B, Mileo V, Venturi L, Moretti E, Blackaby WP, Patacchini R, Accetta A, Biagetti M, Bassani F, Tondelli M, Murgo A, Battipaglia L, Villetti G, Puccini P, Catinella S, Civelli M, Rancati F. Carzaniga L, et al. Among authors: miglietta d. J Med Chem. 2022 Aug 11;65(15):10233-10250. doi: 10.1021/acs.jmedchem.2c00609. Epub 2022 Jul 28. J Med Chem. 2022. PMID: 35901125
Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques.
Oriano M, Terranova L, Sotgiu G, Saderi L, Bellofiore A, Retucci M, Marotta C, Gramegna A, Miglietta D, Carnini C, Marchisio P, Chalmers JD, Aliberti S, Blasi F. Oriano M, et al. Among authors: miglietta d. Pulm Pharmacol Ther. 2019 Dec;59:101856. doi: 10.1016/j.pupt.2019.101856. Epub 2019 Oct 15. Pulm Pharmacol Ther. 2019. PMID: 31626976
Synthesis of novel nitric oxide (NO)-releasing esters of timolol.
Chiroli V, Batugo MR, Biondi S, Bonfanti A, Brambilla S, Gale DC, Li L, Miglietta D, Nicoli F, Prasanna GA, Ronchetti D, Vernier WF, Chong WK. Chiroli V, et al. Among authors: miglietta d. Bioorg Med Chem Lett. 2009 May 15;19(10):2785-8. doi: 10.1016/j.bmcl.2009.03.111. Epub 2009 Mar 27. Bioorg Med Chem Lett. 2009. PMID: 19361986
Neutrophil elastase in bronchiectasis.
Gramegna A, Amati F, Terranova L, Sotgiu G, Tarsia P, Miglietta D, Calderazzo MA, Aliberti S, Blasi F. Gramegna A, et al. Among authors: miglietta d. Respir Res. 2017 Dec 19;18(1):211. doi: 10.1186/s12931-017-0691-x. Respir Res. 2017. PMID: 29258516 Free PMC article. Review.
Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy.
Uaesoontrachoon K, Quinn JL, Tatem KS, Van Der Meulen JH, Yu Q, Phadke A, Miller BK, Gordish-Dressman H, Ongini E, Miglietta D, Nagaraju K. Uaesoontrachoon K, et al. Among authors: miglietta d. Hum Mol Genet. 2014 Jun 15;23(12):3239-49. doi: 10.1093/hmg/ddu033. Epub 2014 Jan 23. Hum Mol Genet. 2014. PMID: 24463621 Free PMC article.
Enhanced oxygen saturation in optic nerve head of non-human primate eyes following the intravitreal injection of NCX 434, an innovative nitric oxide-donating glucocorticoid.
Khoobehi B, Chiroli V, Ronchetti D, Miglietta D, Thompson H, Ongini E, Impagnatiello F. Khoobehi B, et al. Among authors: miglietta d. J Ocul Pharmacol Ther. 2011 Apr;27(2):115-21. doi: 10.1089/jop.2010.0150. Epub 2011 Mar 17. J Ocul Pharmacol Ther. 2011. PMID: 21413860 Free PMC article.
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