Migawa MT - Search Results

1

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Among authors: migawa mt. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929

2

Synthesis and biological activity of 5-fluorotubercidin.

Wang X, Seth PP, Ranken R, Swayze EE, Migawa MT. Wang X, et al. Among authors: migawa mt. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):161-70. doi: 10.1081/ncn-120027825. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15043144

3

Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.

Lima WF, Nichols JG, Wu H, Prakash TP, Migawa MT, Wyrzykiewicz TK, Bhat B, Crooke ST. Lima WF, et al. Among authors: migawa mt. J Biol Chem. 2004 Aug 27;279(35):36317-26. doi: 10.1074/jbc.M405035200. Epub 2004 Jun 17. J Biol Chem. 2004. PMID: 15205459 Free article.

4

Aryl urea analogs with broad-spectrum antibacterial activity.

Seth PP, Ranken R, Robinson DE, Osgood SA, Risen LM, Rodgers EL, Migawa MT, Jefferson EA, Swayze EE. Seth PP, et al. Among authors: migawa mt. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5569-72. doi: 10.1016/j.bmcl.2004.08.059. Bioorg Med Chem Lett. 2004. PMID: 15482926

5

The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

Lima WF, Rose JB, Nichols JG, Wu H, Migawa MT, Wyrzykiewicz TK, Vasquez G, Swayze EE, Crooke ST. Lima WF, et al. Among authors: migawa mt. Mol Pharmacol. 2007 Jan;71(1):73-82. doi: 10.1124/mol.106.025429. Epub 2006 Oct 6. Mol Pharmacol. 2007. PMID: 17028157

6

Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.

Lima WF, Rose JB, Nichols JG, Wu H, Migawa MT, Wyrzykiewicz TK, Siwkowski AM, Crooke ST. Lima WF, et al. Among authors: migawa mt. Mol Pharmacol. 2007 Jan;71(1):83-91. doi: 10.1124/mol.106.025015. Epub 2006 Oct 6. Mol Pharmacol. 2007. PMID: 17028158

7

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals.

Swayze EE, Siwkowski AM, Wancewicz EV, Migawa MT, Wyrzykiewicz TK, Hung G, Monia BP, Bennett CF. Swayze EE, et al. Among authors: migawa mt. Nucleic Acids Res. 2007;35(2):687-700. doi: 10.1093/nar/gkl1071. Epub 2006 Dec 19. Nucleic Acids Res. 2007. PMID: 17182632 Free PMC article.

8

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Kinberger G, Migawa MT, Gaus H, Bhat B, Swayze EE. Seth PP, et al. Among authors: migawa mt. Nucleic Acids Symp Ser (Oxf). 2008;(52):553-4. doi: 10.1093/nass/nrn280. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776499

9

Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.

Prakash TP, Siwkowski A, Allerson CR, Migawa MT, Lee S, Gaus HJ, Black C, Seth PP, Swayze EE, Bhat B. Prakash TP, et al. Among authors: migawa mt. J Med Chem. 2010 Feb 25;53(4):1636-50. doi: 10.1021/jm9013295. J Med Chem. 2010. PMID: 20108935

10

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. Among authors: migawa mt. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

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