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Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D, Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D, Dopeso H, Croft L, Richardson MF, Sieber OM, Liao Y, Mooi JK, Vukelic N, Reehorst CM, Afshar-Sterle S, Whitehall VLJ, Fennell L, Abud HE, Tebbutt NC, Phillips WA, Williams DS, Shi W, Mielke LA, Ernst M, Dhillon AS, Clemons NJ, Mariadason JM. Luk IY, et al. Among authors: mielke la. Cell Death Differ. 2022 Nov;29(11):2288-2302. doi: 10.1038/s41418-022-01016-w. Epub 2022 May 23. Cell Death Differ. 2022. PMID: 35606410 Free PMC article.
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.
Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A. Vasanthakumar A, et al. Among authors: mielke la. Nat Immunol. 2015 Mar;16(3):276-85. doi: 10.1038/ni.3085. Epub 2015 Jan 19. Nat Immunol. 2015. PMID: 25599561
Deciphering the Innate Lymphoid Cell Transcriptional Program.
Seillet C, Mielke LA, Amann-Zalcenstein DB, Su S, Gao J, Almeida FF, Shi W, Ritchie ME, Naik SH, Huntington ND, Carotta S, Belz GT. Seillet C, et al. Among authors: mielke la. Cell Rep. 2016 Oct 4;17(2):436-447. doi: 10.1016/j.celrep.2016.09.025. Cell Rep. 2016. PMID: 27705792 Free article.
TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis.
Mielke LA, Liao Y, Clemens EB, Firth MA, Duckworth B, Huang Q, Almeida FF, Chopin M, Koay HF, Bell CA, Hediyeh-Zadeh S, Park SL, Raghu D, Choi J, Putoczki TL, Hodgkin PD, Franks AE, Mackay LK, Godfrey DI, Davis MJ, Xue HH, Bryant VL, Kedzierska K, Shi W, Belz GT. Mielke LA, et al. J Exp Med. 2019 Jul 1;216(7):1682-1699. doi: 10.1084/jem.20181778. Epub 2019 May 29. J Exp Med. 2019. PMID: 31142588 Free PMC article.
Loss of NFKB1 Results in Expression of Tumor Necrosis Factor and Activation of Signal Transducer and Activator of Transcription 1 to Promote Gastric Tumorigenesis in Mice.
Low JT, Christie M, Ernst M, Dumoutier L, Preaudet A, Ni Y, Griffin MDW, Mielke LA, Strasser A, Putoczki TL, O'Reilly LA. Low JT, et al. Among authors: mielke la. Gastroenterology. 2020 Oct;159(4):1444-1458.e15. doi: 10.1053/j.gastro.2020.06.039. Epub 2020 Jun 20. Gastroenterology. 2020. PMID: 32569771
TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
Yakou MH, Ghilas S, Tran K, Liao Y, Afshar-Sterle S, Kumari A, Schmid K, Dijkstra C, Inguanti C, Ostrouska S, Wilcox J, Smith M, Parathan P, Allam A, Xue HH, Belz GT, Mariadason JM, Behren A, Drummond GR, Ruscher R, Williams DS, Pal B, Shi W, Ernst M, Raghu D, Mielke LA. Yakou MH, et al. Among authors: mielke la. Sci Immunol. 2023 Oct 13;8(88):eadf2163. doi: 10.1126/sciimmunol.adf2163. Epub 2023 Oct 6. Sci Immunol. 2023. PMID: 37801516
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking.
Tran S, Juliani J, Harris TJ, Evangelista M, Ratcliffe J, Ellis SL, Baloyan D, Reehorst CM, Nightingale R, Luk IY, Jenkins LJ, Ghilas S, Yakou MH, Inguanti C, Johnson C, Buchert M, Lee JC, De Cruz P, Duszyc K, Gleeson PA, Kile BT, Mielke LA, Yap AS, Mariadason JM, Douglas Fairlie W, Lee EF. Tran S, et al. Among authors: mielke la. Commun Biol. 2024 Feb 20;7(1):209. doi: 10.1038/s42003-024-05890-7. Commun Biol. 2024. PMID: 38378743 Free PMC article.
53 results