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An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals.
Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon JL, Scrutton NS. Carbonell P, et al. Among authors: micklefield j. Commun Biol. 2018 Jun 8;1:66. doi: 10.1038/s42003-018-0076-9. eCollection 2018. Commun Biol. 2018. PMID: 30271948 Free PMC article.
Reengineering orthogonally selective riboswitches.
Dixon N, Duncan JN, Geerlings T, Dunstan MS, McCarthy JE, Leys D, Micklefield J. Dixon N, et al. Among authors: micklefield j. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2830-5. doi: 10.1073/pnas.0911209107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133756 Free PMC article.
Orthogonal riboswitches for tuneable coexpression in bacteria.
Dixon N, Robinson CJ, Geerlings T, Duncan JN, Drummond SP, Micklefield J. Dixon N, et al. Among authors: micklefield j. Angew Chem Int Ed Engl. 2012 Apr 10;51(15):3620-4. doi: 10.1002/anie.201109106. Epub 2012 Mar 1. Angew Chem Int Ed Engl. 2012. PMID: 22383398 No abstract available.
Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block.
Diez V, Loznik M, Taylor S, Winn M, Rattray NJ, Podmore H, Micklefield J, Goodacre R, Medema MH, Müller U, Bovenberg R, Janssen DB, Takano E. Diez V, et al. Among authors: micklefield j. ACS Synth Biol. 2015 Jul 17;4(7):796-807. doi: 10.1021/sb500368w. Epub 2015 Mar 9. ACS Synth Biol. 2015. PMID: 25713978
Minimum Information about a Biosynthetic Gene cluster.
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R… See abstract for full author list ➔ Medema MH, et al. Among authors: micklefield j. Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. Nat Chem Biol. 2015. PMID: 26284661 Free PMC article. No abstract available.
SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.
Carbonell P, Currin A, Dunstan M, Fellows D, Jervis A, Rattray NJ, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon JL, Goble C, Goodacre R, Kell DB, Feuvre RL, Micklefield J, Scrutton NS, Shapira P, Takano E, Turner NJ. Carbonell P, et al. Among authors: micklefield j. Biochem Soc Trans. 2016 Jun 15;44(3):675-7. doi: 10.1042/BST20160009. Biochem Soc Trans. 2016. PMID: 27284023 Free PMC article.
93 results