Extrusion without a motor: a new take on the loop extrusion model of genome organization.
Brackley CA, Johnson J, Michieletto D, Morozov AN, Nicodemi M, Cook PR, Marenduzzo D.
Brackley CA, et al. Among authors: michieletto d.
Nucleus. 2018 Jan 1;9(1):95-103. doi: 10.1080/19491034.2017.1421825.
Nucleus. 2018.
PMID: 29300120
Free PMC article.
Our simulations uncover an interesting ratchet effect (where an osmotic pressure promotes loop growth), and suggest, by comparison to recent in vitro and in vivo measurements, that diffusive extrusion can in principle generate loops of the size observed in the data. Extra View on …
Our simulations uncover an interesting ratchet effect (where an osmotic pressure promotes loop growth), and suggest, by comparison to recent …