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Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
Gomez JL, Bonaventura J, Lesniak W, Mathews WB, Sysa-Shah P, Rodriguez LA, Ellis RJ, Richie CT, Harvey BK, Dannals RF, Pomper MG, Bonci A, Michaelides M. Gomez JL, et al. Among authors: michaelides m. Science. 2017 Aug 4;357(6350):503-507. doi: 10.1126/science.aan2475. Science. 2017. PMID: 28774929 Free PMC article.
Motivational valence is determined by striatal melanocortin 4 receptors.
Klawonn AM, Fritz M, Nilsson A, Bonaventura J, Shionoya K, Mirrasekhian E, Karlsson U, Jaarola M, Granseth B, Blomqvist A, Michaelides M, Engblom D. Klawonn AM, et al. Among authors: michaelides m. J Clin Invest. 2018 Jul 2;128(7):3160-3170. doi: 10.1172/JCI97854. Epub 2018 Jun 18. J Clin Invest. 2018. PMID: 29911992 Free PMC article.
Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity.
Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang GJ, Volkow ND, Hurd YL. Michaelides M, et al. Mol Psychiatry. 2020 Sep;25(9):2058-2069. doi: 10.1038/s41380-018-0120-7. Epub 2018 Jun 28. Mol Psychiatry. 2020. PMID: 29955167 Free PMC article.
Ultrapotent chemogenetics for research and potential clinical applications.
Magnus CJ, Lee PH, Bonaventura J, Zemla R, Gomez JL, Ramirez MH, Hu X, Galvan A, Basu J, Michaelides M, Sternson SM. Magnus CJ, et al. Among authors: michaelides m. Science. 2019 Apr 12;364(6436):eaav5282. doi: 10.1126/science.aav5282. Epub 2019 Mar 14. Science. 2019. PMID: 30872534 Free PMC article.
Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.
Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, Greenblatt AD, Jacobson AE, Rice KC, Casadó V, Newman AH, Winkelman JW, Michaelides M, Weintraub E, Volkow ND, Belcher AM, Ferré S. Cai NS, et al. Among authors: michaelides m. J Clin Invest. 2019 Mar 26;129(7):2730-2744. doi: 10.1172/JCI126912. J Clin Invest. 2019. PMID: 30913037 Free PMC article.
Ultrastructural localization of DREADDs in monkeys.
Galvan A, Raper J, Hu X, Paré JF, Bonaventura J, Richie CT, Michaelides M, Mueller SAL, Roseboom PH, Oler JA, Kalin NH, Hall RA, Smith Y. Galvan A, et al. Among authors: michaelides m. Eur J Neurosci. 2019 Sep;50(5):2801-2813. doi: 10.1111/ejn.14429. Epub 2019 Jun 19. Eur J Neurosci. 2019. PMID: 31063250 Free PMC article.
High-potency ligands for DREADD imaging and activation in rodents and monkeys.
Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z. Nat Commun. 2019. PMID: 31604917 Free PMC article.
Designer Receptors Exclusively Activated by Designer Drugs Approach to Treatment of Sleep-disordered Breathing.
Fleury Curado T, Pho H, Freire C, Amorim MR, Bonaventura J, Kim LJ, Lee R, Cabassa ME, Streeter SR, Branco LG, Sennes LU, Fishbein K, Spencer RG, Schwartz AR, Brennick MJ, Michaelides M, Fuller DD, Polotsky VY. Fleury Curado T, et al. Among authors: michaelides m. Am J Respir Crit Care Med. 2021 Jan 1;203(1):102-110. doi: 10.1164/rccm.202002-0321OC. Am J Respir Crit Care Med. 2021. PMID: 32673075 Free PMC article.
663 results