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Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity.
Laudette M, Sainte-Marie Y, Cousin G, Bergonnier D, Belhabib I, Brun S, Formoso K, Laib L, Tortosa F, Bergoglio C, Marcheix B, Borén J, Lairez O, Fauconnier J, Lucas A, Mialet-Perez J, Moro C, Lezoualc'h F. Laudette M, et al. Among authors: mialet perez j. Cell Death Dis. 2021 Sep 1;12(9):824. doi: 10.1038/s41419-021-04113-9. Cell Death Dis. 2021. PMID: 34471096 Free PMC article.
p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice.
Villeneuve C, Guilbeau-Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, De Paulis D, Couderc B, Spreux-Varoquaux O, Tortosa F, Garnier A, Knauf C, Valet P, Borchi E, Nediani C, Gharib A, Ovize M, Delisle MB, Parini A, Mialet-Perez J. Villeneuve C, et al. Antioxid Redox Signal. 2013 Jan 1;18(1):5-18. doi: 10.1089/ars.2011.4373. Epub 2012 Aug 10. Antioxid Redox Signal. 2013. PMID: 22738191 Free PMC article.
Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure.
Santin Y, Sicard P, Vigneron F, Guilbeau-Frugier C, Dutaur M, Lairez O, Couderc B, Manni D, Korolchuk VI, Lezoualc'h F, Parini A, Mialet-Perez J. Santin Y, et al. Antioxid Redox Signal. 2016 Jul 1;25(1):10-27. doi: 10.1089/ars.2015.6522. Epub 2016 Apr 22. Antioxid Redox Signal. 2016. PMID: 26959532
Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
Fazal L, Laudette M, Paula-Gomes S, Pons S, Conte C, Tortosa F, Sicard P, Sainte-Marie Y, Bisserier M, Lairez O, Lucas A, Roy J, Ghaleh B, Fauconnier J, Mialet-Perez J, Lezoualc'h F. Fazal L, et al. Circ Res. 2017 Feb 17;120(4):645-657. doi: 10.1161/CIRCRESAHA.116.309859. Epub 2017 Jan 17. Circ Res. 2017. PMID: 28096195 Free article.
54 results