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Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine.
Mossad O, Batut B, Yilmaz B, Dokalis N, Mezö C, Nent E, Nabavi LS, Mayer M, Maron FJM, Buescher JM, de Agüero MG, Szalay A, Lämmermann T, Macpherson AJ, Ganal-Vonarburg SC, Backofen R, Erny D, Prinz M, Blank T. Mossad O, et al. Among authors: mezo c. Nat Neurosci. 2022 Mar;25(3):295-305. doi: 10.1038/s41593-022-01027-3. Epub 2022 Mar 3. Nat Neurosci. 2022. PMID: 35241804
Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease.
Mezö C, Dokalis N, Mossad O, Staszewski O, Neuber J, Yilmaz B, Schnepf D, de Agüero MG, Ganal-Vonarburg SC, Macpherson AJ, Meyer-Luehmann M, Staeheli P, Blank T, Prinz M, Erny D. Mezö C, et al. Acta Neuropathol Commun. 2020 Jul 29;8(1):119. doi: 10.1186/s40478-020-00988-5. Acta Neuropathol Commun. 2020. PMID: 32727612 Free PMC article.
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease.
Erny D, Dokalis N, Mezö C, Castoldi A, Mossad O, Staszewski O, Frosch M, Villa M, Fuchs V, Mayer A, Neuber J, Sosat J, Tholen S, Schilling O, Vlachos A, Blank T, Gomez de Agüero M, Macpherson AJ, Pearce EJ, Prinz M. Erny D, et al. Among authors: mezo c. Cell Metab. 2021 Nov 2;33(11):2260-2276.e7. doi: 10.1016/j.cmet.2021.10.010. Cell Metab. 2021. PMID: 34731656 Free article.
Microglia contribute to the propagation of Aβ into unaffected brain tissue.
d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M. d'Errico P, et al. Among authors: mezo c. Nat Neurosci. 2022 Jan;25(1):20-25. doi: 10.1038/s41593-021-00951-0. Epub 2021 Nov 22. Nat Neurosci. 2022. PMID: 34811521 Free PMC article.
Lithium and glutamine synthetase: Protective effects following stress.
Mundorf A, Knorr A, Mezö C, Klein C, Beyer DK, Fallgatter AJ, Schwarz M, Freund N. Mundorf A, et al. Among authors: mezo c. Psychiatry Res. 2019 Nov;281:112544. doi: 10.1016/j.psychres.2019.112544. Epub 2019 Aug 30. Psychiatry Res. 2019. PMID: 31499341