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Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis.
Herold T, Schneider S, Metzeler KH, Neumann M, Hartmann L, Roberts KG, Konstandin NP, Greif PA, Bräundl K, Ksienzyk B, Huk N, Schneider I, Zellmeier E, Jurinovic V, Mansmann U, Hiddemann W, Mullighan CG, Bohlander SK, Spiekermann K, Hoelzer D, Brüggemann M, Baldus CD, Dreyling M, Gökbuget N. Herold T, et al. Among authors: metzeler kh. Haematologica. 2017 Jan;102(1):130-138. doi: 10.3324/haematol.2015.136366. Epub 2016 Aug 25. Haematologica. 2017. PMID: 27561722 Free PMC article.
Efficacy and safety of bemcentinib in patients with advanced myelodysplastic neoplasms or acute myeloid leukemia failing hypomethylating agents- the EMSCO phase II BERGAMO trial.
Kubasch AS, Peterlin P, Cluzeau T, Götze KS, Sockel K, Teipel R, Jentzsch M, Attalah H, Sebert M, Chermat F, Gloaguen S, Puttrich M, Cross M, Schneider M, Kayser S, Schipp D, Giagounidis A, Tirado-Gonzalez I, Descot A, van de Loosdrecht A, Weigert A, Metzeler KH, Fenaux P, Medyouf H, Platzbecker U, Ades L. Kubasch AS, et al. Among authors: metzeler kh. Leukemia. 2023 Nov;37(11):2309-2313. doi: 10.1038/s41375-023-02029-1. Epub 2023 Sep 21. Leukemia. 2023. PMID: 37735558 Free PMC article. Clinical Trial. No abstract available.
Activation of distinct inflammatory pathways in subgroups of LR-MDS.
Schneider M, Rolfs C, Trumpp M, Winter S, Fischer L, Richter M, Menger V, Nenoff K, Grieb N, Metzeler KH, Kubasch AS, Sockel K, Thiede C, Wu J, Woo J, Brüderle A, Hofbauer LC, Lützner J, Roth A, Cross M, Platzbecker U. Schneider M, et al. Among authors: metzeler kh. Leukemia. 2023 Aug;37(8):1709-1718. doi: 10.1038/s41375-023-01949-2. Epub 2023 Jul 7. Leukemia. 2023. PMID: 37420006 Free PMC article.
[Diagnostics and therapy of acute myeloid leukemia].
Fritsch S, Metzeler K, Hiddemann W, Buske C. Fritsch S, et al. Dtsch Med Wochenschr. 2006 Oct 27;131(43):2401-6. doi: 10.1055/s-2006-955022. Dtsch Med Wochenschr. 2006. PMID: 17054056 Review. German. No abstract available.
[Fortuitous finding: thrombocytopenia and thrombocytosis].
Metzeler KH, Braess J, Spiekermann K, Bohlander SK, Hiddemann W, Buske C, Feuring-Buske M. Metzeler KH, et al. MMW Fortschr Med. 2007 Apr 12;149(15):34-5, 37. MMW Fortschr Med. 2007. PMID: 17668774 German.
Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia.
Rawat VP, Thoene S, Naidu VM, Arseni N, Heilmeier B, Metzeler K, Petropoulos K, Deshpande A, Quintanilla-Martinez L, Bohlander SK, Spiekermann K, Hiddemann W, Feuring-Buske M, Buske C. Rawat VP, et al. Blood. 2008 Jan 1;111(1):309-19. doi: 10.1182/blood-2007-04-085407. Epub 2007 Sep 12. Blood. 2008. PMID: 17855634 Free article.
An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia.
Metzeler KH, Hummel M, Bloomfield CD, Spiekermann K, Braess J, Sauerland MC, Heinecke A, Radmacher M, Marcucci G, Whitman SP, Maharry K, Paschka P, Larson RA, Berdel WE, Büchner T, Wörmann B, Mansmann U, Hiddemann W, Bohlander SK, Buske C; Cancer and Leukemia Group B; German AML Cooperative Group. Metzeler KH, et al. Blood. 2008 Nov 15;112(10):4193-201. doi: 10.1182/blood-2008-02-134411. Epub 2008 Aug 20. Blood. 2008. PMID: 18716133 Free PMC article. Clinical Trial.
ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays.
Metzeler KH, Dufour A, Benthaus T, Hummel M, Sauerland MC, Heinecke A, Berdel WE, Büchner T, Wörmann B, Mansmann U, Braess J, Spiekermann K, Hiddemann W, Buske C, Bohlander SK. Metzeler KH, et al. J Clin Oncol. 2009 Oct 20;27(30):5031-8. doi: 10.1200/JCO.2008.20.5328. Epub 2009 Sep 14. J Clin Oncol. 2009. PMID: 19752345
148 results