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Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT. White MJ, et al. Among authors: metcalf d. Cell. 2014 Dec 18;159(7):1549-62. doi: 10.1016/j.cell.2014.11.036. Cell. 2014. PMID: 25525874 Free PMC article.
Programmed anuclear cell death delimits platelet life span.
Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT. Mason KD, et al. Among authors: metcalf d. Cell. 2007 Mar 23;128(6):1173-86. doi: 10.1016/j.cell.2007.01.037. Cell. 2007. PMID: 17382885 Free article.
IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.
Croker BA, Kiu H, Pellegrini M, Toe J, Preston S, Metcalf D, O'Donnell JA, Cengia LH, McArthur K, Nicola NA, Alexander WS, Roberts AW. Croker BA, et al. Among authors: metcalf d. Immunol Cell Biol. 2012 Jan;90(1):124-9. doi: 10.1038/icb.2011.29. Epub 2011 Apr 26. Immunol Cell Biol. 2012. PMID: 21519345 Free PMC article.
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Josefsson EC, et al. Among authors: metcalf d. J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911424 Free PMC article.
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker BA. Masters SL, et al. Among authors: metcalf d. Immunity. 2012 Dec 14;37(6):1009-23. doi: 10.1016/j.immuni.2012.08.027. Epub 2012 Dec 6. Immunity. 2012. PMID: 23219391 Free PMC article.
IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.
Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL. Murphy AJ, et al. Among authors: metcalf d. Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22. Cell Metab. 2016. PMID: 26603191 Free article.
Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.
Okamoto T, Coultas L, Metcalf D, van Delft MF, Glaser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Huang DC. Okamoto T, et al. Among authors: metcalf d. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6. doi: 10.1073/pnas.1321259110. Epub 2013 Dec 20. Proc Natl Acad Sci U S A. 2014. PMID: 24363325 Free PMC article.
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.
Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts AW, Kastner DL, Lew AM, Lyras D, Kile BT, Croker BA, Masters SL. Kim ML, et al. Among authors: metcalf d. J Exp Med. 2015 Jun 1;212(6):927-38. doi: 10.1084/jem.20142384. Epub 2015 May 25. J Exp Med. 2015. PMID: 26008898 Free PMC article.
774 results