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A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement.
D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. D'Ippolito RA, et al. Among authors: messing s. Anal Chem. 2024 Apr 2;96(13):5223-5231. doi: 10.1021/acs.analchem.3c05626. Epub 2024 Mar 18. Anal Chem. 2024. PMID: 38498381 Free PMC article.
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.
Lakshman B, Messing S, Schmid EM, Clogston JD, Gillette WK, Esposito D, Kessing B, Fletcher DA, Nissley DV, McCormick F, Stephen AG, Jean-Francois FL. Lakshman B, et al. Among authors: messing s. J Biol Chem. 2019 Feb 8;294(6):2193-2207. doi: 10.1074/jbc.RA118.005669. Epub 2018 Dec 17. J Biol Chem. 2019. PMID: 30559287 Free PMC article.
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Whitley MJ, Tran TH, Rigby M, Yi M, Dharmaiah S, Waybright TJ, Ramakrishnan N, Perkins S, Taylor T, Messing S, Esposito D, Nissley DV, McCormick F, Stephen AG, Turbyville T, Cornilescu G, Simanshu DK. Whitley MJ, et al. Among authors: messing s. Sci Adv. 2024 Feb 16;10(7):eadj4137. doi: 10.1126/sciadv.adj4137. Epub 2024 Feb 14. Sci Adv. 2024. PMID: 38354232 Free article.
Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.
Sherekar M, Han SW, Ghirlando R, Messing S, Drew M, Rabara D, Waybright T, Juneja P, O'Neill H, Stanley CB, Bhowmik D, Ramanathan A, Subramaniam S, Nissley DV, Gillette W, McCormick F, Esposito D. Sherekar M, et al. Among authors: messing s. J Biol Chem. 2020 Jan 24;295(4):1105-1119. doi: 10.1074/jbc.RA119.010934. Epub 2019 Dec 13. J Biol Chem. 2020. PMID: 31836666 Free PMC article.
157 results