Mesens N - Search Results

1

Chemistry-Based Modeling on Phenotype-Based Drug-Induced Liver Injury Annotation: From Public to Proprietary Data.

Moein M, Heinonen M, Mesens N, Chamanza R, Amuzie C, Will Y, Ceulemans H, Kaski S, Herman D. Moein M, et al. Among authors: mesens n. Chem Res Toxicol. 2023 Aug 21;36(8):1238-1247. doi: 10.1021/acs.chemrestox.2c00378. Epub 2023 Aug 9. Chem Res Toxicol. 2023. PMID: 37556769 Free PMC article.

2

Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure-Activity Relationship Models.

Herman D, Kańduła MM, Freitas LGA, van Dongen C, Le Van T, Mesens N, Jaensch S, Gustin E, Micholt L, Lardeau CH, Varsakelis C, Reumers J, Zoffmann S, Will Y, Peeters PJ, Ceulemans H. Herman D, et al. Among authors: mesens n. Chem Res Toxicol. 2023 Jul 17;36(7):1028-1036. doi: 10.1021/acs.chemrestox.2c00404. Epub 2023 Jun 16. Chem Res Toxicol. 2023. PMID: 37327474 Free PMC article.

3

Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.

Weaver RJ, Betts C, Blomme EAG, Gerets HHJ, Gjervig Jensen K, Hewitt PG, Juhila S, Labbe G, Liguori MJ, Mesens N, Ogese MO, Persson M, Snoeys J, Stevens JL, Walker T, Park BK. Weaver RJ, et al. Among authors: mesens n. Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):767-782. doi: 10.1080/17425255.2017.1341489. Epub 2017 Jun 28. Expert Opin Drug Metab Toxicol. 2017. PMID: 28604124 Review.

4

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

Mesens N, Crawford AD, Menke A, Hung PD, Van Goethem F, Nuyts R, Hansen E, Wolterbeek A, Van Gompel J, De Witte P, Esguerra CV. Mesens N, et al. J Appl Toxicol. 2015 Sep;35(9):1017-29. doi: 10.1002/jat.3091. Epub 2015 Feb 6. J Appl Toxicol. 2015. PMID: 25663337

5

Screening for phospholipidosis induced by central nervous drugs: comparing the predictivity of an in vitro assay to high throughput in silico assays.

Mesens N, Steemans M, Hansen E, Verheyen GR, Van Goethem F, Van Gompel J. Mesens N, et al. Toxicol In Vitro. 2010 Aug;24(5):1417-25. doi: 10.1016/j.tiv.2010.04.007. Epub 2010 Apr 27. Toxicol In Vitro. 2010. PMID: 20430096

6

Evaluation of the embryotoxic potency of compounds in a newly revised high throughput embryonic stem cell test.

Peters AK, Steemans M, Hansen E, Mesens N, Verheyen GR, Vanparys P. Peters AK, et al. Among authors: mesens n. Toxicol Sci. 2008 Oct;105(2):342-50. doi: 10.1093/toxsci/kfn126. Epub 2008 Jun 30. Toxicol Sci. 2008. PMID: 18593728

7

Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?

Van den Bulck K, Hill A, Mesens N, Diekman H, De Schaepdrijver L, Lammens L. Van den Bulck K, et al. Among authors: mesens n. Reprod Toxicol. 2011 Sep;32(2):213-9. doi: 10.1016/j.reprotox.2011.06.119. Epub 2011 Jun 21. Reprod Toxicol. 2011. PMID: 21704152

8

Phospholipidosis in rats treated with amiodarone: serum biochemistry and whole genome micro-array analysis supporting the lipid traffic jam hypothesis and the subsequent rise of the biomarker BMP.

Mesens N, Desmidt M, Verheyen GR, Starckx S, Damsch S, De Vries R, Verhemeldonck M, Van Gompel J, Lampo A, Lammens L. Mesens N, et al. Toxicol Pathol. 2012 Apr;40(3):491-503. doi: 10.1177/0192623311432290. Epub 2012 Jan 30. Toxicol Pathol. 2012. PMID: 22291062

9

Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development.

Hill A, Mesens N, Steemans M, Xu JJ, Aleo MD. Hill A, et al. Among authors: mesens n. Drug Metab Rev. 2012 Feb;44(1):127-40. doi: 10.3109/03602532.2011.645578. Drug Metab Rev. 2012. PMID: 22242931 Review.

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