Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

141 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor.
Bose S, Steussy CN, López-Pérez D, Schmidt T, Kulathunga SC, Seleem MN, Lipton M, Mesecar AD, Rodwell VW, Stauffacher CV. Bose S, et al. Among authors: mesecar ad. Commun Biol. 2023 Apr 3;6(1):360. doi: 10.1038/s42003-023-04639-y. Commun Biol. 2023. PMID: 37012403 Free PMC article.
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors.
Ghosh AK, Yadav M, Iddum S, Ghazi S, Lendy EK, Jayashankar U, Beechboard SN, Takamatsu Y, Hattori SI, Aamano M, Higashi-Kuwata N, Mitsuya H, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Eur J Med Chem. 2024 Mar 5;267:116132. doi: 10.1016/j.ejmech.2024.116132. Epub 2024 Feb 1. Eur J Med Chem. 2024. PMID: 38335815
A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease.
Visvanathan R, Utsuki T, Beck DE, Lendy E, Sun KL, Liu Y, Hering KW, Mesecar A, Zhang ZY, Putt KS. Visvanathan R, et al. SLAS Discov. 2023 Jun;28(4):170-179. doi: 10.1016/j.slasd.2023.03.003. Epub 2023 Mar 17. SLAS Discov. 2023. PMID: 36933698 Free PMC article.
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease.
Jesudason CD, Mason ER, Chu S, Oblak AL, Javens-Wolfe J, Moussaif M, Durst G, Hipskind P, Beck DE, Dong J, Amarasinghe O, Zhang ZY, Hamdani AK, Singhal K, Mesecar AD, Souza S, Jacobson M, Salvo JD, Soni DM, Kandasamy M, Masters AR, Quinney SK, Doolen S, Huhe H, Rizzo SJS, Lamb BT, Palkowitz AD, Richardson TI. Jesudason CD, et al. Among authors: mesecar ad. Alzheimers Dement (N Y). 2023 Nov 17;9(4):e12429. doi: 10.1002/trc2.12429. eCollection 2023 Oct-Dec. Alzheimers Dement (N Y). 2023. PMID: 38023622 Free PMC article.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Tsai AP, Dong C, Lin PB, Oblak AL, Viana Di Prisco G, Wang N, Hajicek N, Carr AJ, Lendy EK, Hahn O, Atkins M, Foltz AG, Patel J, Xu G, Moutinho M, Sondek J, Zhang Q, Mesecar AD, Liu Y, Atwood BK, Wyss-Coray T, Nho K, Bissel SJ, Lamb BT, Landreth GE. Tsai AP, et al. Among authors: mesecar ad. Immunity. 2023 Sep 12;56(9):2121-2136.e6. doi: 10.1016/j.immuni.2023.08.008. Epub 2023 Sep 1. Immunity. 2023. PMID: 37659412 Free article.
141 results