Mesecar AD - Search Results

1

Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.

Ghosh AK, Raghavaiah J, Shahabi D, Yadav M, Anson BJ, Lendy EK, Hattori SI, Higashi-Kuwata N, Mitsuya H, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. J Med Chem. 2021 Oct 14;64(19):14702-14714. doi: 10.1021/acs.jmedchem.1c01214. Epub 2021 Sep 16. J Med Chem. 2021. PMID: 34528437 Free PMC article.

2

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.

Ghosh AK, Xi K, Grum-Tokars V, Xu X, Ratia K, Fu W, Houser KV, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5876-80. doi: 10.1016/j.bmcl.2007.08.031. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17855091 Free PMC article.

3

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.

Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8. doi: 10.1016/j.bmcl.2008.08.082. Epub 2008 Aug 28. Bioorg Med Chem Lett. 2008. PMID: 18796354 Free PMC article.

4

Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation.

Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. J Med Chem. 2010 Jul 8;53(13):4968-79. doi: 10.1021/jm1004489. J Med Chem. 2010. PMID: 20527968 Free PMC article.

5

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.

St John SE, Therkelsen MD, Nyalapatla PR, Osswald HL, Ghosh AK, Mesecar AD. St John SE, et al. Among authors: mesecar ad. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5072-7. doi: 10.1016/j.bmcl.2015.10.023. Epub 2015 Oct 13. Bioorg Med Chem Lett. 2015. PMID: 26592814 Free PMC article.

6

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.

Ghosh AK, Brindisi M, Yen YC, Cárdenas EL, Ella-Menye JR, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2432-2438. doi: 10.1016/j.bmcl.2017.04.011. Epub 2017 Apr 8. Bioorg Med Chem Lett. 2017. PMID: 28427814 Free PMC article.

7

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.

Ghosh AK, Ghosh K, Brindisi M, Lendy EK, Yen YC, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2605-2610. doi: 10.1016/j.bmcl.2018.06.045. Epub 2018 Jun 26. Bioorg Med Chem Lett. 2018. PMID: 29970308 Free PMC article.

8

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.

Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H. Hattori SI, et al. Among authors: mesecar ad. Nat Commun. 2021 Jan 28;12(1):668. doi: 10.1038/s41467-021-20900-6. Nat Commun. 2021. PMID: 33510133 Free PMC article.

9

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.

Ghosh AK, Shahabi D, Yadav M, Kovela S, Anson BJ, Lendy EK, Bonham C, Sirohi D, Brito-Sierra CA, Hattori SI, Kuhn R, Mitsuya H, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Molecules. 2021 Sep 24;26(19):5782. doi: 10.3390/molecules26195782. Molecules. 2021. PMID: 34641337 Free PMC article.

10

Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS-CoV-2 Infection and COVID-19.

Ghosh AK, Mishevich JL, Mesecar A, Mitsuya H. Ghosh AK, et al. ChemMedChem. 2022 Nov 18;17(22):e202200440. doi: 10.1002/cmdc.202200440. Epub 2022 Oct 13. ChemMedChem. 2022. PMID: 36165855 Free PMC article. Review.

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