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Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.
Ferrante F, Giaimo BD, Friedrich T, Sugino T, Mertens D, Kugler S, Gahr BM, Just S, Pan L, Bartkuhn M, Potente M, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: mertens d. Cell Death Dis. 2022 Jul 12;13(7):600. doi: 10.1038/s41419-022-05052-9. Cell Death Dis. 2022. PMID: 35821235 Free PMC article.
Missing the notch in NOTCH1.
Kugler SJ, Schnaiter A, Stilgenbauer S, Mertens D. Kugler SJ, et al. Among authors: mertens d. Leuk Lymphoma. 2013 Aug;54(8):1579-80. doi: 10.3109/10428194.2013.767459. Epub 2013 Feb 16. Leuk Lymphoma. 2013. PMID: 23323947 No abstract available.
HDAC3 functions as a positive regulator in Notch signal transduction.
Ferrante F, Giaimo BD, Bartkuhn M, Zimmermann T, Close V, Mertens D, Nist A, Stiewe T, Meier-Soelch J, Kracht M, Just S, Klöble P, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: mertens d. Nucleic Acids Res. 2020 Apr 17;48(7):3496-3512. doi: 10.1093/nar/gkaa088. Nucleic Acids Res. 2020. PMID: 32107550 Free PMC article.
Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks.
Mallm JP, Iskar M, Ishaque N, Klett LC, Kugler SJ, Muino JM, Teif VB, Poos AM, Großmann S, Erdel F, Tavernari D, Koser SD, Schumacher S, Brors B, König R, Remondini D, Vingron M, Stilgenbauer S, Lichter P, Zapatka M, Mertens D, Rippe K. Mallm JP, et al. Among authors: mertens d. Mol Syst Biol. 2019 May 22;15(5):e8339. doi: 10.15252/msb.20188339. Mol Syst Biol. 2019. PMID: 31118277 Free PMC article.
Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.
Yosifov DY, Idler I, Bhattacharya N, Reichenzeller M, Close V, Ezerina D, Scheffold A, Jebaraj BMC, Kugler S, Bloehdorn J, Bahlo J, Robrecht S, Eichhorst B, Fischer K, Weigel A, Busch H, Lichter P, Döhner H, Dick TP, Stilgenbauer S, Mertens D. Yosifov DY, et al. Among authors: mertens d. Leukemia. 2020 Jan;34(1):115-127. doi: 10.1038/s41375-019-0513-x. Epub 2019 Jul 12. Leukemia. 2020. PMID: 31300746
CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling.
Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, Martin D, Walcher D, Döhner K, Döhner H, Claus R, Plass C, Sykes SM, Lane SW, Scholl C, Fröhling S. Faber K, et al. Among authors: mertens d. J Clin Invest. 2013 Jan;123(1):299-314. doi: 10.1172/JCI64745. Epub 2012 Dec 3. J Clin Invest. 2013. PMID: 23202735 Free PMC article.
NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.
Schnaiter A, Paschka P, Rossi M, Zenz T, Bühler A, Winkler D, Cazzola M, Döhner K, Edelmann J, Mertens D, Kless S, Mack S, Busch R, Hallek M, Döhner H, Stilgenbauer S. Schnaiter A, et al. Among authors: mertens d. Blood. 2013 Aug 15;122(7):1266-70. doi: 10.1182/blood-2013-03-488197. Epub 2013 Jul 2. Blood. 2013. PMID: 23821658 Free article. Clinical Trial.
Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling.
Filarsky K, Garding A, Becker N, Wolf C, Zucknick M, Claus R, Weichenhan D, Plass C, Döhner H, Stilgenbauer S, Lichter P, Mertens D. Filarsky K, et al. Among authors: mertens d. Haematologica. 2016 Jun;101(6):e249-53. doi: 10.3324/haematol.2015.138172. Epub 2016 Apr 14. Haematologica. 2016. PMID: 27081174 Free PMC article. No abstract available.
265 results