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Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Mersal KI, Abdel-Maksoud MS, Ali EMH, Ammar UM, Zaraei SO, Haque MM, Das T, Hassan NF, Kim EE, Lee JS, Park H, Lee KH, El-Gamal MI, Kim HK, Ibrahim TM, Oh CH. Mersal KI, et al. Eur J Med Chem. 2023 Dec 5;261:115779. doi: 10.1016/j.ejmech.2023.115779. Epub 2023 Sep 15. Eur J Med Chem. 2023. PMID: 37776574
Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAFV600E/p38α kinase inhibitory activity: Synthesis, in vitro assays and in silico study.
Ali EMH, Mersal KI, Ammar UM, Zaraei SO, Abdel-Maksoud MS, El-Gamal MI, Haque MM, Das T, Kim EE, Lee JS, Lee KH, Kim HK, Oh CH. Ali EMH, et al. Among authors: mersal ki. Eur J Pharm Sci. 2022 Apr 1;171:106115. doi: 10.1016/j.ejps.2022.106115. Epub 2022 Jan 4. Eur J Pharm Sci. 2022. PMID: 34995782 Free article.
Discovery of New Imidazo[2,1-b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity.
Abdel-Maksoud MS, El-Gamal MI, Lee BS, Gamal El-Din MM, Jeon HR, Kwon D, Ammar UM, Mersal KI, Ali EMH, Lee KT, Yoo KH, Han DK, Lee JK, Kim G, Choi HS, Kwon YJ, Lee KH, Oh CH. Abdel-Maksoud MS, et al. Among authors: mersal ki. J Med Chem. 2021 May 27;64(10):6877-6901. doi: 10.1021/acs.jmedchem.1c00230. Epub 2021 May 17. J Med Chem. 2021. PMID: 33999621 Free article.
Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors.
Ali EMH, El-Telbany RFA, Abdel-Maksoud MS, Ammar UM, Mersal KI, Zaraei SO, El-Gamal MI, Choi SI, Lee KT, Kim HK, Lee KH, Oh CH. Ali EMH, et al. Among authors: mersal ki. Eur J Med Chem. 2021 Apr 5;215:113277. doi: 10.1016/j.ejmech.2021.113277. Epub 2021 Feb 7. Eur J Med Chem. 2021. PMID: 33601311 Free article.