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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M. Jobava R, et al. Among authors: merrick wc. Mol Cell. 2021 Oct 21;81(20):4191-4208.e8. doi: 10.1016/j.molcel.2021.09.029. Mol Cell. 2021. PMID: 34686314 Free PMC article.
A Unique ISR Program Determines Cellular Responses to Chronic Stress.
Guan BJ, van Hoef V, Jobava R, Elroy-Stein O, Valasek LS, Cargnello M, Gao XH, Krokowski D, Merrick WC, Kimball SR, Komar AA, Koromilas AE, Wynshaw-Boris A, Topisirovic I, Larsson O, Hatzoglou M. Guan BJ, et al. Among authors: merrick wc. Mol Cell. 2017 Dec 7;68(5):885-900.e6. doi: 10.1016/j.molcel.2017.11.007. Mol Cell. 2017. PMID: 29220654 Free PMC article.
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M. Krokowski D, et al. Among authors: merrick wc. Cell Rep. 2022 Jul 19;40(3):111092. doi: 10.1016/j.celrep.2022.111092. Cell Rep. 2022. PMID: 35858571 Free PMC article.
Characterization of hibernating ribosomes in mammalian cells.
Krokowski D, Gaccioli F, Majumder M, Mullins MR, Yuan CL, Papadopoulou B, Merrick WC, Komar AA, Taylor D, Hatzoglou M. Krokowski D, et al. Among authors: merrick wc. Cell Cycle. 2011 Aug 15;10(16):2691-702. doi: 10.4161/cc.10.16.16844. Epub 2011 Aug 15. Cell Cycle. 2011. PMID: 21768774 Free PMC article.
The eIF2A knockout mouse.
Golovko A, Kojukhov A, Guan BJ, Morpurgo B, Merrick WC, Mazumder B, Hatzoglou M, Komar AA. Golovko A, et al. Among authors: merrick wc. Cell Cycle. 2016 Nov 16;15(22):3115-3120. doi: 10.1080/15384101.2016.1237324. Epub 2016 Sep 29. Cell Cycle. 2016. PMID: 27686860 Free PMC article.
eIF2A-knockout mice reveal decreased life span and metabolic syndrome.
Anderson R, Agarwal A, Ghosh A, Guan BJ, Casteel J, Dvorina N, Baldwin WM 3rd, Mazumder B, Nazarko TY, Merrick WC, Buchner DA, Hatzoglou M, Kondratov RV, Komar AA. Anderson R, et al. Among authors: merrick wc. FASEB J. 2021 Nov;35(11):e21990. doi: 10.1096/fj.202101105R. FASEB J. 2021. PMID: 34665898 Free PMC article.
201 results