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New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.
Alvarez G, Martínez J, Aguirre-López B, Cabrera N, Pérez-Díaz L, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Garat B, Merlino A, González M, Cerecetto H. Alvarez G, et al. Among authors: merlino a. J Enzyme Inhib Med Chem. 2014 Apr;29(2):198-204. doi: 10.3109/14756366.2013.765415. Epub 2013 Feb 13. J Enzyme Inhib Med Chem. 2014. PMID: 23406473
Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.
Alvarez G, Aguirre-López B, Varela J, Cabrera M, Merlino A, López GV, Lavaggi ML, Porcal W, Di Maio R, González M, Cerecetto H, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A. Alvarez G, et al. Among authors: merlino a. Eur J Med Chem. 2010 Dec;45(12):5767-72. doi: 10.1016/j.ejmech.2010.09.034. Epub 2010 Sep 19. Eur J Med Chem. 2010. PMID: 20889239
Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.
Aguilera E, Varela J, Birriel E, Serna E, Torres S, Yaluff G, de Bilbao NV, Aguirre-López B, Cabrera N, Díaz Mazariegos S, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Minini L, Merlino A, Cerecetto H, González M, Alvarez G. Aguilera E, et al. Among authors: merlino a. ChemMedChem. 2016 Jun 20;11(12):1328-38. doi: 10.1002/cmdc.201500385. Epub 2015 Oct 23. ChemMedChem. 2016. PMID: 26492824
Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.
Porcal W, Hernández P, Aguirre G, Boiani L, Boiani M, Merlino A, Ferreira A, Maio RD, Castro A, González M, Cerecetto H. Porcal W, et al. Among authors: merlino a. Bioorg Med Chem. 2007 Apr 1;15(7):2768-81. doi: 10.1016/j.bmc.2007.01.009. Epub 2007 Jan 12. Bioorg Med Chem. 2007. PMID: 17287123
Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents.
Caputto ME, Fabian LE, Benítez D, Merlino A, Ríos N, Cerecetto H, Moltrasio GY, Moglioni AG, González M, Finkielsztein LM. Caputto ME, et al. Among authors: merlino a. Bioorg Med Chem. 2011 Nov 15;19(22):6818-26. doi: 10.1016/j.bmc.2011.09.037. Epub 2011 Sep 24. Bioorg Med Chem. 2011. PMID: 22000947
283 results