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Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C-CDH5 inhibition.
Sung DC, Chen M, Dominguez MH, Mahadevan A, Chen X, Yang J, Gao S, Ren AA, Tang AT, Mericko P, Patton R, Lee M, Jannaway M, Nottebaum A, Vestweber D, Scallan JP, Kahn ML. Sung DC, et al. Among authors: mericko p. Nat Cardiovasc Res. 2022 Nov;1(11):1006-1021. doi: 10.1038/s44161-022-00147-0. Epub 2022 Nov 11. Nat Cardiovasc Res. 2022. PMID: 36910472 Free PMC article.
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML. Ren AA, et al. Among authors: mericko p. Nature. 2021 Jun;594(7862):271-276. doi: 10.1038/s41586-021-03562-8. Epub 2021 Apr 28. Nature. 2021. PMID: 33910229 Free PMC article.
Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.
Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA. Polster SP, et al. Among authors: mericko p. Nat Commun. 2020 May 27;11(1):2659. doi: 10.1038/s41467-020-16436-w. Nat Commun. 2020. PMID: 32461638 Free PMC article.
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML. Tang AT, et al. Among authors: mericko p. Nature. 2017 May 18;545(7654):305-310. doi: 10.1038/nature22075. Epub 2017 May 10. Nature. 2017. PMID: 28489816 Free PMC article.
Blood flow reprograms lymphatic vessels to blood vessels.
Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L, Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML. Chen CY, et al. Among authors: mericko p. J Clin Invest. 2012 Jun;122(6):2006-17. doi: 10.1172/JCI57513. Epub 2012 May 24. J Clin Invest. 2012. PMID: 22622036 Free PMC article.
Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease.
Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML. Schmaier AA, et al. Among authors: mericko p. Blood. 2011 Sep 29;118(13):3661-9. doi: 10.1182/blood-2011-02-338244. Epub 2011 Aug 3. Blood. 2011. PMID: 21816834 Free PMC article.
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.
Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML. Bertozzi CC, et al. Among authors: mericko p. Blood. 2010 Jul 29;116(4):661-70. doi: 10.1182/blood-2010-02-270876. Epub 2010 Apr 2. Blood. 2010. PMID: 20363774 Free PMC article.
Klf2 is an essential regulator of vascular hemodynamic forces in vivo.
Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML. Lee JS, et al. Among authors: mericko p. Dev Cell. 2006 Dec;11(6):845-57. doi: 10.1016/j.devcel.2006.09.006. Dev Cell. 2006. PMID: 17141159 Free article.
18 results