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Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands.
Mercier J, Archen L, Bollu V, Carré S, Evrard Y, Jnoff E, Kenda B, Lallemand B, Michel P, Montel F, Moureau F, Price N, Quesnel Y, Sauvage X, Valade A, Provins L. Mercier J, et al. ChemMedChem. 2014 Apr;9(4):693-8. doi: 10.1002/cmdc.201300482. Epub 2014 Jan 20. ChemMedChem. 2014. PMID: 24446373
A general copper-mediated nucleophilic 18F fluorination of arenes.
Tredwell M, Preshlock SM, Taylor NJ, Gruber S, Huiban M, Passchier J, Mercier J, Génicot C, Gouverneur V. Tredwell M, et al. Among authors: mercier j. Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7751-5. doi: 10.1002/anie.201404436. Epub 2014 Jun 10. Angew Chem Int Ed Engl. 2014. PMID: 24916101
Evaluation of 18F-UCB-H as a novel PET tracer for synaptic vesicle protein 2A in the brain.
Warnock GI, Aerts J, Bahri MA, Bretin F, Lemaire C, Giacomelli F, Mievis F, Mestdagh N, Buchanan T, Valade A, Mercier J, Wood M, Gillard M, Seret A, Luxen A, Salmon E, Plenevaux A. Warnock GI, et al. Among authors: mercier j. J Nucl Med. 2014 Aug;55(8):1336-41. doi: 10.2967/jnumed.113.136143. Epub 2014 Jun 16. J Nucl Med. 2014. PMID: 24935992 Free article.
Enhanced copper-mediated (18)F-fluorination of aryl boronic esters provides eight radiotracers for PET applications.
Preshlock S, Calderwood S, Verhoog S, Tredwell M, Huiban M, Hienzsch A, Gruber S, Wilson TC, Taylor NJ, Cailly T, Schedler M, Collier TL, Passchier J, Smits R, Mollitor J, Hoepping A, Mueller M, Genicot C, Mercier J, Gouverneur V. Preshlock S, et al. Among authors: mercier j. Chem Commun (Camb). 2016 Jun 28;52(54):8361-4. doi: 10.1039/c6cc03295h. Chem Commun (Camb). 2016. PMID: 27241832
Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent 18F-Labeled Ligand ([18F]UCB-H).
Warnier C, Lemaire C, Becker G, Zaragoza G, Giacomelli F, Aerts J, Otabashi M, Bahri MA, Mercier J, Plenevaux A, Luxen A. Warnier C, et al. Among authors: mercier j. J Med Chem. 2016 Oct 13;59(19):8955-8966. doi: 10.1021/acs.jmedchem.6b00905. Epub 2016 Sep 20. J Med Chem. 2016. PMID: 27598384
Bridging the gaps in 18F PET tracer development.
Campbell MG, Mercier J, Genicot C, Gouverneur V, Hooker JM, Ritter T. Campbell MG, et al. Among authors: mercier j. Nat Chem. 2016 Dec 20;9(1):1-3. doi: 10.1038/nchem.2693. Nat Chem. 2016. PMID: 27995923 No abstract available.
1,117 results