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A general copper-mediated nucleophilic 18F fluorination of arenes.
Tredwell M, Preshlock SM, Taylor NJ, Gruber S, Huiban M, Passchier J, Mercier J, Génicot C, Gouverneur V. Tredwell M, et al. Among authors: mercier j. Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7751-5. doi: 10.1002/anie.201404436. Epub 2014 Jun 10. Angew Chem Int Ed Engl. 2014. PMID: 24916101
Enhanced copper-mediated (18)F-fluorination of aryl boronic esters provides eight radiotracers for PET applications.
Preshlock S, Calderwood S, Verhoog S, Tredwell M, Huiban M, Hienzsch A, Gruber S, Wilson TC, Taylor NJ, Cailly T, Schedler M, Collier TL, Passchier J, Smits R, Mollitor J, Hoepping A, Mueller M, Genicot C, Mercier J, Gouverneur V. Preshlock S, et al. Among authors: mercier j. Chem Commun (Camb). 2016 Jun 28;52(54):8361-4. doi: 10.1039/c6cc03295h. Chem Commun (Camb). 2016. PMID: 27241832
Bridging the gaps in 18F PET tracer development.
Campbell MG, Mercier J, Genicot C, Gouverneur V, Hooker JM, Ritter T. Campbell MG, et al. Among authors: mercier j. Nat Chem. 2016 Dec 20;9(1):1-3. doi: 10.1038/nchem.2693. Nat Chem. 2016. PMID: 27995923 No abstract available.
Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands.
Mercier J, Archen L, Bollu V, Carré S, Evrard Y, Jnoff E, Kenda B, Lallemand B, Michel P, Montel F, Moureau F, Price N, Quesnel Y, Sauvage X, Valade A, Provins L. Mercier J, et al. ChemMedChem. 2014 Apr;9(4):693-8. doi: 10.1002/cmdc.201300482. Epub 2014 Jan 20. ChemMedChem. 2014. PMID: 24446373
Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent 18F-Labeled Ligand ([18F]UCB-H).
Warnier C, Lemaire C, Becker G, Zaragoza G, Giacomelli F, Aerts J, Otabashi M, Bahri MA, Mercier J, Plenevaux A, Luxen A. Warnier C, et al. Among authors: mercier j. J Med Chem. 2016 Oct 13;59(19):8955-8966. doi: 10.1021/acs.jmedchem.6b00905. Epub 2016 Sep 20. J Med Chem. 2016. PMID: 27598384
Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.
Bahri MA, Plenevaux A, Aerts J, Bastin C, Becker G, Mercier J, Valade A, Buchanan T, Mestdagh N, Ledoux D, Seret A, Luxen A, Salmon E. Bahri MA, et al. Among authors: mercier j. Alzheimers Dement (N Y). 2017 Aug 30;3(4):481-486. doi: 10.1016/j.trci.2017.08.004. eCollection 2017 Nov. Alzheimers Dement (N Y). 2017. PMID: 29124105 Free PMC article.
Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.
Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Finnema SJ, et al. Among authors: mercier j. J Cereb Blood Flow Metab. 2018 Nov;38(11):2041-2052. doi: 10.1177/0271678X17724947. Epub 2017 Aug 9. J Cereb Blood Flow Metab. 2018. PMID: 28792356 Free PMC article.
1,117 results