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A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.
PLoS Pathog. 2018 Jan 16;14(1):e1006826. doi: 10.1371/journal.ppat.1006826. eCollection 2018 Jan.
PLoS Pathog. 2018.
PMID: 29338055
Free PMC article.
The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D.
Mercer RC, et al.
J Biol Chem. 2013 Dec 27;288(52):37241-55. doi: 10.1074/jbc.M113.488650. Epub 2013 Nov 13.
J Biol Chem. 2013.
PMID: 24225951
Free PMC article.
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Endoproteolytic processing of the mammalian prion glycoprotein family.
Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D.
Mays CE, et al.
FEBS J. 2014 Feb;281(3):862-76. doi: 10.1111/febs.12654. Epub 2013 Dec 23.
FEBS J. 2014.
PMID: 24286250
Free article.
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Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.
Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D.
Lau A, et al.
EMBO Mol Med. 2015 Mar;7(3):339-56. doi: 10.15252/emmm.201404588.
EMBO Mol Med. 2015.
PMID: 25661904
Free PMC article.
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Prions activate a p38 MAPK synaptotoxic signaling pathway.
Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA.
Fang C, et al. Among authors: mercer rcc.
PLoS Pathog. 2018 Sep 20;14(9):e1007283. doi: 10.1371/journal.ppat.1007283. eCollection 2018 Sep.
PLoS Pathog. 2018.
PMID: 30235355
Free PMC article.
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Mechanisms of prion-induced toxicity.
Mercer RCC, Harris DA.
Mercer RCC, et al.
Cell Tissue Res. 2023 Apr;392(1):81-96. doi: 10.1007/s00441-022-03683-0. Epub 2022 Sep 7.
Cell Tissue Res. 2023.
PMID: 36070155
Review.
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Vertebrate slow skeletal muscle actin - conservation, distribution and conformational flexibility.
Mercer RC, Mudalige WA, Ige TO, Heeley DH.
Mercer RC, et al.
Biochim Biophys Acta. 2011 Oct;1814(10):1253-60. doi: 10.1016/j.bbapap.2011.06.009. Epub 2011 Jun 23.
Biochim Biophys Acta. 2011.
PMID: 21722757
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Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding.
Mercer RCC, Le NTT, Houser MCQ, Beeler AB, Harris DA.
Mercer RCC, et al.
bioRxiv [Preprint]. 2023 Nov 29:2023.11.28.569035. doi: 10.1101/2023.11.28.569035.
bioRxiv. 2023.
PMID: 38077011
Free PMC article.
Preprint.
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