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Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery.
Haydar D, Houke H, Chiang J, Yi Z, Odé Z, Caldwell K, Zhu X, Mercer KS, Stripay JL, Shaw TI, Vogel P, DeRenzo C, Baker SJ, Roussel MF, Gottschalk S, Krenciute G. Haydar D, et al. Among authors: mercer ks. Neuro Oncol. 2021 Jun 1;23(6):999-1011. doi: 10.1093/neuonc/noaa278. Neuro Oncol. 2021. PMID: 33320196 Free PMC article.
Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource.
Smith KS, Xu K, Mercer KS, Boop F, Klimo P, DeCupyere M, Grenet J, Robinson S, Dunphy P, Baker SJ, Ellison DW, Merchant TE, Upadayaya SA, Gajjar A, Wu G, Orr BA, Robinson GW, Northcott PA, Roussel MF. Smith KS, et al. Among authors: mercer ks. Acta Neuropathol. 2020 Aug;140(2):209-225. doi: 10.1007/s00401-020-02171-5. Epub 2020 Jun 10. Acta Neuropathol. 2020. PMID: 32519082 Free PMC article.
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
He C, Xu K, Zhu X, Dunphy PS, Gudenas B, Lin W, Twarog N, Hover LD, Kwon CH, Kasper LH, Zhang J, Li X, Dalton J, Jonchere B, Mercer KS, Currier DG, Caufield W, Wang Y, Xie J, Broniscer A, Wetmore C, Upadhyaya SA, Qaddoumi I, Klimo P, Boop F, Gajjar A, Zhang J, Orr BA, Robinson GW, Monje M, Freeman Iii BB, Roussel MF, Northcott PA, Chen T, Rankovic Z, Wu G, Chiang J, Tinkle CL, Shelat AA, Baker SJ. He C, et al. Among authors: mercer ks. Nat Commun. 2021 Jul 2;12(1):4089. doi: 10.1038/s41467-021-24168-8. Nat Commun. 2021. PMID: 34215733 Free PMC article.
Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.
Paassen I, Williams J, Ríos Arceo C, Ringnalda F, Mercer KS, Buhl JL, Moreno N, Federico A, Franke NE, Kranendonk M, Upadhyaya SA, Kerl K, van de Wetering M, Clevers H, Kool M, Hoving EW, Roussel MF, Drost J. Paassen I, et al. Among authors: mercer ks. Oncogene. 2023 May;42(20):1661-1671. doi: 10.1038/s41388-023-02681-y. Epub 2023 Apr 5. Oncogene. 2023. PMID: 37020038 Free PMC article.
Evaluation of ABT-751 against childhood cancer models in vivo.
Morton CL, Favours EG, Mercer KS, Boltz CR, Crumpton JC, Tucker C, Billups CA, Houghton PJ. Morton CL, et al. Among authors: mercer ks. Invest New Drugs. 2007 Aug;25(4):285-95. doi: 10.1007/s10637-007-9042-y. Epub 2007 Mar 24. Invest New Drugs. 2007. PMID: 17384918