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Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice.
Morrison MC, Mulder P, Salic K, Verheij J, Liang W, van Duyvenvoorde W, Menke A, Kooistra T, Kleemann R, Wielinga PY. Morrison MC, et al. Among authors: menke a. Int J Obes (Lond). 2016 Sep;40(9):1416-23. doi: 10.1038/ijo.2016.74. Epub 2016 May 28. Int J Obes (Lond). 2016. PMID: 27121255 Free PMC article.
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice.
Morrison MC, Verschuren L, Salic K, Verheij J, Menke A, Wielinga PY, Iruarrizaga-Lejarreta M, Gole L, Yu WM, Turner S, Caspers MPM, Martínez-Arranz I, Pieterman E, Stoop R, van Koppen A, van den Hoek AM, Mato JM, Hanemaaijer R, Alonso C, Kleemann R. Morrison MC, et al. Among authors: menke a. Hepatol Commun. 2018 Oct 29;2(12):1513-1532. doi: 10.1002/hep4.1270. eCollection 2018 Dec. Hepatol Commun. 2018. PMID: 30556039 Free PMC article.
Cholesterol Accumulation as a Driver of Hepatic Inflammation Under Translational Dietary Conditions Can Be Attenuated by a Multicomponent Medicine.
Mueller AM, Kleemann R, Gart E, van Duyvenvoorde W, Verschuren L, Caspers M, Menke A, Krömmelbein N, Salic K, Burmeister Y, Seilheimer B, Morrison MC. Mueller AM, et al. Among authors: menke a. Front Endocrinol (Lausanne). 2021 Mar 18;12:601160. doi: 10.3389/fendo.2021.601160. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33815271 Free PMC article.
Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk.
van den Hoek AM, de Jong JCBC, Worms N, van Nieuwkoop A, Voskuilen M, Menke AL, Lek S, Caspers MPM, Verschuren L, Kleemann R. van den Hoek AM, et al. Among authors: menke al. Metabolism. 2021 Nov;124:154873. doi: 10.1016/j.metabol.2021.154873. Epub 2021 Sep 1. Metabolism. 2021. PMID: 34478753 Free article.
Butyrate Protects against Diet-Induced NASH and Liver Fibrosis and Suppresses Specific Non-Canonical TGF-β Signaling Pathways in Human Hepatic Stellate Cells.
Gart E, van Duyvenvoorde W, Toet K, Caspers MPM, Verschuren L, Nielsen MJ, Leeming DJ, Souto Lima E, Menke A, Hanemaaijer R, Keijer J, Salic K, Kleemann R, Morrison MC. Gart E, et al. Among authors: menke a. Biomedicines. 2021 Dec 20;9(12):1954. doi: 10.3390/biomedicines9121954. Biomedicines. 2021. PMID: 34944770 Free PMC article.
266 results