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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, Ahmad T, Allez M, Ananthakrishnan AN, Atzmon G, Baras A, Barrett JC, Barzilai N, Beaugerie L, Beecham A, Bernstein CN, Bitton A, Bokemeyer B, Chan A, Chung D, Cleynen I, Cosnes J, Cutler DJ, Daly A, Damas OM, Datta LW, Dawany N, Devoto M, Dodge S, Ellinghaus E, Fachal L, Farkkila M, Faubion W, Ferreira M, Franchimont D, Gabriel SB, Ge T, Georges M, Gettler K, Giri M, Glaser B, Goerg S, Goyette P, Graham D, Hämäläinen E, Haritunians T, Heap GA, Hiltunen M, Hoeppner M, Horowitz JE, Irving P, Iyer V, Jalas C, Kelsen J, Khalili H, Kirschner BS, Kontula K, Koskela JT, Kugathasan S, Kupcinskas J, Lamb CA, Laudes M, Lévesque C, Levine AP, Lewis JD, Liefferinckx C, Loescher BS, Louis E, Mansfield J, May S, McCauley JL, Mengesha E, Mni M, Moayyedi P, Moran CJ, Newberry RD, O'Charoen S, Okou DT, Oldenburg B, Ostrer H, Palotie A, Paquette J, Pekow J, Peter I, Pierik MJ, Ponsioen CY, Pontikos N, Prescott N, Pulver AE, Rahmouni S, Rice DL, Saavalainen P, Sands B, Sartor RB, Schiff ER, Schreiber S, Schumm LP, Segal AW, Seksik P, Shawky R, Sheikh SZ, Silverberg MS, Simmons A, Skeiceviciene J, Sokol H, Solomonson M, Somine… See abstract for full author list ➔ Sazonovs A, et al. Among authors: mengesha e. Nat Genet. 2022 Sep;54(9):1275-1283. doi: 10.1038/s41588-022-01156-2. Epub 2022 Aug 29. Nat Genet. 2022. PMID: 36038634 Free PMC article.
IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.
Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI; Western Regional Research Alliance for Pediatric IBD. Dubinsky MC, et al. Among authors: mengesha e. Inflamm Bowel Dis. 2007 May;13(5):511-5. doi: 10.1002/ibd.20126. Inflamm Bowel Dis. 2007. PMID: 17309073 Free PMC article.
MAGI2 genetic variation and inflammatory bowel disease.
McGovern DP, Taylor KD, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mei L, Mengesha E, King L, Pressman S, Targan SR, Rotter JI. McGovern DP, et al. Among authors: mengesha e. Inflamm Bowel Dis. 2009 Jan;15(1):75-83. doi: 10.1002/ibd.20611. Inflamm Bowel Dis. 2009. PMID: 18720471 Free PMC article.
Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.
McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD. McGovern DP, et al. Among authors: mengesha e. Inflamm Bowel Dis. 2009 Jun;15(6):883-9. doi: 10.1002/ibd.20855. Inflamm Bowel Dis. 2009. PMID: 19235914 Free PMC article.
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI; International IBD Genetics Consortium. McGovern DP, et al. Among authors: mengesha e. Hum Mol Genet. 2010 Sep 1;19(17):3468-76. doi: 10.1093/hmg/ddq248. Epub 2010 Jun 22. Hum Mol Genet. 2010. PMID: 20570966 Free PMC article.
Genetic predictors of medically refractory ulcerative colitis.
Haritunians T, Taylor KD, Targan SR, Dubinsky M, Ippoliti A, Kwon S, Guo X, Melmed GY, Berel D, Mengesha E, Psaty BM, Glazer NL, Vasiliauskas EA, Rotter JI, Fleshner PR, McGovern DP. Haritunians T, et al. Among authors: mengesha e. Inflamm Bowel Dis. 2010 Nov;16(11):1830-40. doi: 10.1002/ibd.21293. Inflamm Bowel Dis. 2010. PMID: 20848476 Free PMC article.
Variants in ZNF365 isoform D are associated with Crohn's disease.
Haritunians T, Jones MR, McGovern DP, Shih DQ, Barrett RJ, Derkowski C, Dubinsky MC, Dutridge D, Fleshner PR, Ippoliti A, King L, Leshinsky-Silver E, Levine A, Melmed GY, Mengesha E, Vasilauskas EA, Ziaee S, Rotter JI, Targan SR, Taylor KD. Haritunians T, et al. Among authors: mengesha e. Gut. 2011 Aug;60(8):1060-7. doi: 10.1136/gut.2010.227256. Epub 2011 Jan 21. Gut. 2011. PMID: 21257989 Free PMC article.
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