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Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction.
Vistnes M, Erusappan PM, Sasi A, Nordén ES, Bergo KK, Romaine A, Lunde IG, Zhang L, Olsen MB, Øgaard J, Carlson CR, Wang CH, Riise J, Dahl CP, Fiane AE, Hauge-Iversen IM, Espe E, Melleby AO, Tønnessen T, Aronsen JM, Sjaastad I, Christensen G. Vistnes M, et al. Among authors: melleby ao. Cardiovasc Res. 2023 Aug 19;119(10):1915-1927. doi: 10.1093/cvr/cvad078. Cardiovasc Res. 2023. PMID: 37216909 Free PMC article.
Overexpression of integrin α11 induces cardiac fibrosis in mice.
Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D. Romaine A, et al. Among authors: melleby ao. Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12932. Epub 2017 Aug 30. Acta Physiol (Oxf). 2018. PMID: 28771943
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin.
Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G. Herum KM, et al. Among authors: melleby ao. J Am Heart Assoc. 2020 Feb 4;9(3):e013518. doi: 10.1161/JAHA.119.013518. Epub 2020 Jan 31. J Am Heart Assoc. 2020. PMID: 32000579 Free PMC article.
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors.
Manfra O, Calamera G, Froese A, Arunthavarajah D, Surdo NC, Meier S, Melleby AO, Aasrum M, Aronsen JM, Nikolaev VO, Zaccolo M, Moltzau LR, Levy FO, Andressen KW. Manfra O, et al. Among authors: melleby ao. Cardiovasc Res. 2022 May 6;118(6):1506-1519. doi: 10.1093/cvr/cvab167. Cardiovasc Res. 2022. PMID: 33970224 Free PMC article.
17 results