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Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.
Iannielli A, Luoni M, Giannelli SG, Ferese R, Ordazzo G, Fossati M, Raimondi A, Opazo F, Corti O, Prehn JHM, Gambardella S, Melki R, Broccoli V. Iannielli A, et al. Among authors: melki r. Cell Death Dis. 2022 Oct 19;13(10):881. doi: 10.1038/s41419-022-05330-6. Cell Death Dis. 2022. PMID: 36261424 Free PMC article.
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD. Bieri G, et al. Among authors: melki r. Acta Neuropathol. 2019 Jun;137(6):961-980. doi: 10.1007/s00401-019-01995-0. Epub 2019 Mar 29. Acta Neuropathol. 2019. PMID: 30927072 Free PMC article.
Protein Quality Control Pathways at the Crossroad of Synucleinopathies.
De Mattos EP, Wentink A, Nussbaum-Krammer C, Hansen C, Bergink S, Melki R, Kampinga HH. De Mattos EP, et al. Among authors: melki r. J Parkinsons Dis. 2020;10(2):369-382. doi: 10.3233/JPD-191790. J Parkinsons Dis. 2020. PMID: 31985474 Free PMC article. Review.
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.
Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, Van den Haute C, Gentleman S, Melki R, Baekelandt V. Van der Perren A, et al. Among authors: melki r. Acta Neuropathol. 2020 Jun;139(6):977-1000. doi: 10.1007/s00401-020-02157-3. Epub 2020 Apr 30. Acta Neuropathol. 2020. PMID: 32356200 Free PMC article.
244 results