Melillo B - Search Results

1

Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides.

Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, Lim KS, Poirier J, Capece J, Bonazzi S, Gampe CM, Smith NJ, Bradner JE, Coley CW, Clemons PA, Melillo B, Hon CS, Ottl J, Dumelin CE, Schaefer JV, Faust AME, Berst F, Schreiber SL, Zécri FJ, Briner K. Hudson L, et al. Among authors: melillo b. Nat Commun. 2023 Nov 21;14(1):7589. doi: 10.1038/s41467-023-43518-2. Nat Commun. 2023. PMID: 37989745 Free PMC article. No abstract available.

2

Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp³)-H Arylation.

Maetani M, Zoller J, Melillo B, Verho O, Kato N, Pu J, Comer E, Schreiber SL. Maetani M, et al. Among authors: melillo b. J Am Chem Soc. 2017 Aug 16;139(32):11300-11306. doi: 10.1021/jacs.7b06994. Epub 2017 Aug 7. J Am Chem Soc. 2017. PMID: 28732448 Free PMC article.

3

Stereospecific Palladium-Catalyzed C-H Arylation of Pyroglutamic Acid Derivatives at the C3 Position Enabled by 8-Aminoquinoline as a Directing Group.

Verho O, Maetani M, Melillo B, Zoller J, Schreiber SL. Verho O, et al. Among authors: melillo b. Org Lett. 2017 Sep 1;19(17):4424-4427. doi: 10.1021/acs.orglett.7b01776. Epub 2017 Aug 15. Org Lett. 2017. PMID: 28809506

4

Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds.

Melillo B, Zoller J, Hua BK, Verho O, Borghs JC, Nelson SD Jr, Maetani M, Wawer MJ, Clemons PA, Schreiber SL. Melillo B, et al. J Am Chem Soc. 2018 Sep 19;140(37):11784-11790. doi: 10.1021/jacs.8b07319. Epub 2018 Sep 6. J Am Chem Soc. 2018. PMID: 30133283 Free PMC article.

5

Modular, stereocontrolled C_β-H/C_α-C activation of alkyl carboxylic acids.

Shang M, Feu KS, Vantourout JC, Barton LM, Osswald HL, Kato N, Gagaring K, McNamara CW, Chen G, Hu L, Ni S, Fernández-Canelas P, Chen M, Merchant RR, Qin T, Schreiber SL, Melillo B, Yu JQ, Baran PS. Shang M, et al. Among authors: melillo b. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8721-8727. doi: 10.1073/pnas.1903048116. Epub 2019 Apr 17. Proc Natl Acad Sci U S A. 2019. PMID: 30996125 Free PMC article.

6

Ligand-Enabled β-Methylene C(sp³ )-H Arylation of Masked Aliphatic Alcohols.

Xia G, Zhuang Z, Liu LY, Schreiber SL, Melillo B, Yu JQ. Xia G, et al. Among authors: melillo b. Angew Chem Int Ed Engl. 2020 May 11;59(20):7783-7787. doi: 10.1002/anie.202000632. Epub 2020 Mar 11. Angew Chem Int Ed Engl. 2020. PMID: 32050036 Free PMC article.

7

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.

Sharma M, Malhotra N, Yogavel M, Harlos K, Melillo B, Comer E, Gonse A, Parvez S, Mitasev B, Fang FG, Schreiber SL, Sharma A. Sharma M, et al. Among authors: melillo b. Nat Commun. 2021 Jan 12;12(1):343. doi: 10.1038/s41467-020-20478-5. Nat Commun. 2021. PMID: 33436639 Free PMC article.

8

Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase.

Radke JB, Melillo B, Mittal P, Sharma M, Sharma A, Fu Y, Uddin T, Gonse A, Comer E, Schreiber SL, Gupta AK, Chatterjee AK, Sibley LD. Radke JB, et al. Among authors: melillo b. Nat Commun. 2022 Jan 24;13(1):459. doi: 10.1038/s41467-022-28108-y. Nat Commun. 2022. PMID: 35075105 Free PMC article.

9

Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.

Sharma M, Mutharasappan N, Manickam Y, Harlos K, Melillo B, Comer E, Tabassum H, Parvez S, Schreiber SL, Sharma A. Sharma M, et al. Among authors: melillo b. Structure. 2022 Jul 7;30(7):962-972.e3. doi: 10.1016/j.str.2022.03.017. Epub 2022 Apr 22. Structure. 2022. PMID: 35460612 Free article.

10

Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.

Feldman HC, Merlini E, Guijas C, DeMeester KE, Njomen E, Kozina EM, Yokoyama M, Vinogradova E, Reardon HT, Melillo B, Schreiber SL, Loreto A, Blankman JL, Cravatt BF. Feldman HC, et al. Among authors: melillo b. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119. doi: 10.1073/pnas.2208457119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994671 Free PMC article.

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